| Literature DB >> 12057842 |
Nobuyuki Sasaki1, Masayoshi Takeuchi, Hiroshi Chowei, Seiji Kikuchi, Yorihide Hayashi, Norihito Nakano, Hiroshi Ikeda, Sho-ichi Yamagishi, Tetsuyuki Kitamoto, Toshikazu Saito, Zenji Makita.
Abstract
The objective of this study was to assess the pathological role of advanced glycation end products (AGE) and the receptor for AGE (RAGE) in Creutzfeldt-Jakob disease (CJD). We immunohistochemically investigated the occipital lobe of three patients with CJD containing with prion protein (PrP) plaques using anti-AGE and RAGE antibodies. Many PrP-positive plaques were observed in these patients, and the PrP-positive prion plaques also showed immunoreactivity for the anti-AGE antibody. Furthermore, many astrocytes contained-PrP positive granules, and the same astrocytes also contained many AGE- and RAGE-immunopositive granules. The staining pattern of these granules showed good concordance with that of PrP. These findings suggest that there may be a RAGE-mediated PrP degradation pathway in CJD as is the case for beta-amyloid protein in Alzheimer's disease.Entities:
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Year: 2002 PMID： 12057842 DOI： 10.1016/s0304-3940(02)00310-5
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046