OBJECTIVE: To access the ability of intraperitoneal phospholipids to reduce adhesions in a standardized model for gynecologic operations. DESIGN: A randomized, experimental, blinded study using the double uterine horn model. SETTING: Academic animal research laboratory. ANIMAL(S): Thirty-three Chinchilla rabbits. INTERVENTION(S): Phospholipids or Ringer's lactate were intraperitoneally administered after bilateral uterine horn injury. MAIN OUTCOME MEASURE(S): After 10 days, adhesions were evaluated concerning area and strength as well as scores describing tenacity and degree. RESULT(S): Phospholipids (median 102.1 mm2) significantly reduce adhesion areas in comparison to surgical controls (median 392.2 mm2) and Ringer group (median 323.8 mm2). Scores reflecting severity and degree of adhesions support this finding. CONCLUSION(S): These results prove the efficacy of phospholipids in the double uterine horn model. Future clinical studies are recommended.
OBJECTIVE: To access the ability of intraperitoneal phospholipids to reduce adhesions in a standardized model for gynecologic operations. DESIGN: A randomized, experimental, blinded study using the double uterine horn model. SETTING: Academic animal research laboratory. ANIMAL(S): Thirty-three Chinchilla rabbits. INTERVENTION(S): Phospholipids or Ringer's lactate were intraperitoneally administered after bilateral uterine horn injury. MAIN OUTCOME MEASURE(S): After 10 days, adhesions were evaluated concerning area and strength as well as scores describing tenacity and degree. RESULT(S): Phospholipids (median 102.1 mm2) significantly reduce adhesion areas in comparison to surgical controls (median 392.2 mm2) and Ringer group (median 323.8 mm2). Scores reflecting severity and degree of adhesions support this finding. CONCLUSION(S): These results prove the efficacy of phospholipids in the double uterine horn model. Future clinical studies are recommended.
Authors: M Jansen; J Otto; P Lynen Jansen; M Anurov; S Titkova; S Willis; R Rosch; A Ottinger; V Schumpelick Journal: Surg Endosc Date: 2007-08-19 Impact factor: 4.584
Authors: Nick Butz; Stefan A Müller; Karl-Heinz Treutner; Michail Anurov; Svetlana Titkova; Alexander P Oettinger; Volker Schumpelick Journal: BMC Surg Date: 2007-07-25 Impact factor: 2.102