| Literature DB >> 12057662 |
Alcides J M da Silva1, Camilla D Buarque, Flávia V Brito, Laure Aurelian, Luciana F Macedo, Linda H Malkas, Robert J Hickey, Daniele V S Lopes, François Noël, Yugo L B Murakami, Noelson M V Silva, Paulo A Melo, Rodrigo R B Caruso, Newton G Castro, Paulo R R Costa.
Abstract
Seven new 1,4-naphthoquinones structurally related to lapachol were synthesized from lawsone and oxygenated arylmercurials. These compounds can also be seen as pterocarpan derivatives where the A-ring was substituted by the 1,4-naphthoquinone nucleus. Pharmacological screening provided evidence of significant biological activities, including effects against proliferation of the MCF-7 human breast cancer cell line, against Herpes Simplex Virus type 2 infection, and against snake poison-induced myotoxicity. One derivative displaced flunitrazepam binding and showed benzodiazepine-like activity, suggesting novel neuroactive structural motifs.Entities:
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Year: 2002 PMID： 12057662 DOI： 10.1016/s0968-0896(02)00100-1
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641