| Literature DB >> 12057655 |
Giuseppe Caliendo1, Elisa Perissutti, Vincenzo Santagada, Ferdinando Fiorino, Beatrice Severino, Roberta d'Emmanuele di Villa Bianca, Laura Lippolis, Aldo Pinto, Raffaella Sorrentino.
Abstract
As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives derived from transformation of the benzopyran skeleton of cromakalim were described. Several new 1,4-benzoxazine derivatives were provided with significant vasorelaxant activity with an overall pharmacological behavior similar to CRK (1f, 1i, 2d, 2e, 2f and 2i).Entities:
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Year: 2002 PMID： 12057655 DOI： 10.1016/s0968-0896(02)00091-3
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641