| Literature DB >> 12057651 |
Allan M Jordan1, Tariq H Khan, Hugh Malkin, Helen M I Osborn.
Abstract
The suitability of 4-di(2-chloroethyl)aminoanilino-4-hydroxyphenethylaminomethanone 2 to act as a prodrug for melanocyte-directed enzyme prodrug therapy (MDEPT) is assessed. Thus its synthesis, ability to generate a cytotoxic agent upon exposure to tyrosinase, and stability within different sera are reported. A comparison is made to illustrate that the new urea prodrug 2 is a more suitable candidate for MDEPT than the corresponding carbamate prodrug 1.Entities:
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Year: 2002 PMID： 12057651 DOI： 10.1016/s0968-0896(02)00097-4
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641