Bridging the gap between SCF and ubiquitin transfer.

The first crystal structure of a core SCF complex has been determined to 3.2 A. Together with previous data obtained for RING E3-E2 and Skp1-Skp2 adaptor complexes, the structure provides substantial insight into SCF-mediated protein modification by ubiquitin, a process that regulates protein modification and degradation in systems ranging from cell cycle progression to transcription.