Literature DB >> 12056862

On reducing the statespace of hidden Markov models for the identity by descent process.

Sharon Browning1, Brian L Browning.   

Abstract

Important methods for calculating likelihoods of genealogical relationships and mapping genes are based on hidden Markov models for the process of identity by descent along chromosomes. The computational time for the algorithms depends critically on the size of the statespace of the hidden Markov model. We describe the maximal grouping together of states of the model to reduce the size of the statespace. This grouping is based on pedigree symmetries. We also present an efficient algorithm for finding the maximal grouping. Copyright 2002 Elsevier Science (USA).

Mesh:

Year:  2002        PMID: 12056862     DOI: 10.1006/tpbi.2002.1583

Source DB:  PubMed          Journal:  Theor Popul Biol        ISSN: 0040-5809            Impact factor:   1.570


  6 in total

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5.  Isomorphism and similarity for 2-generation pedigrees.

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6.  Blocks of chromosomes identical by descent in a population: Models and predictions.

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  6 in total

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