OBJECTIVE AND DESIGN: In a prospective trial 266 multiple injured patients were included to evaluate clinical risk factors and immune parameters related to pneumonia. METHODS: Clinical and humoral parameters were assessed and multivariate analysis performed. RESULTS: The multivariate analysis (odds ratio with 95% confidence interval (CI)) revealed male gender (3.65), traumatic brain injury (TBI) (2.52), thorax trauma (AIS(thorax) > or = 3) (2.05), antibiotic prophylaxis (1.30), injury severity score (ISS) (1.03 per ISS point) and the age (1.02 per year) as risk factors for pneumonia. The main pathogens were Acinetobacter Baumannii (40%) and Staphylococcus aureus (25%). A tendency towards higher Procalcitonin (PCT) and Interleukin (IL)-6 levels two days after trauma was observed for pneumonia patients. CONCLUSION: The immune parameters (PCT, IL-6, IL-10, soluble tumor necrosis factor p-55 and p-75) could not confirm the diagnosis of pneumonia earlier than the clinical parameters.
OBJECTIVE AND DESIGN: In a prospective trial 266 multiple injured patients were included to evaluate clinical risk factors and immune parameters related to pneumonia. METHODS: Clinical and humoral parameters were assessed and multivariate analysis performed. RESULTS: The multivariate analysis (odds ratio with 95% confidence interval (CI)) revealed male gender (3.65), traumatic brain injury (TBI) (2.52), thorax trauma (AIS(thorax) > or = 3) (2.05), antibiotic prophylaxis (1.30), injury severity score (ISS) (1.03 per ISS point) and the age (1.02 per year) as risk factors for pneumonia. The main pathogens were Acinetobacter Baumannii (40%) and Staphylococcus aureus (25%). A tendency towards higher Procalcitonin (PCT) and Interleukin (IL)-6 levels two days after trauma was observed for pneumoniapatients. CONCLUSION: The immune parameters (PCT, IL-6, IL-10, soluble tumornecrosis factor p-55 and p-75) could not confirm the diagnosis of pneumonia earlier than the clinical parameters.
Authors: Zhiping Yang; Yuh-Chin T Huang; Henry Koziel; Rini de Crom; Hartmut Ruetten; Paulus Wohlfart; Reimar W Thomsen; Johnny A Kahlert; Henrik Toft Sørensen; Szczepan Jozefowski; Amy Colby; Lester Kobzik Journal: Elife Date: 2014-10-15 Impact factor: 8.140
Authors: Aziza N AlRawahi; Fatma A AlHinai; Christopher J Doig; Chad G Ball; Elijah Dixon; Zhengwen Xiao; Andrew W Kirkpatrick Journal: Crit Care Date: 2019-12-03 Impact factor: 9.097
Authors: Anna Maria Azzini; Romolo Marco Dorizzi; Piersandro Sette; Marta Vecchi; Ilaria Coledan; Elda Righi; Evelina Tacconelli Journal: Ann Transl Med Date: 2020-05