Literature DB >> 12054973

First total synthesis of A(2) isoprostane.

Giuseppe Zanoni1, Alessio Porta, Giovanni Vidari.   

Abstract

A stereoselective Julia-Lythgoe olefination has allowed the first total synthesis of A(2) isoprostane (1), a recently discovered member of the growing isoprostane family. This elusive compound opens up numerous new avenues for the molecular biology of cyclopentenone prostaglandins, which are endowed of intriguing biological effects such as antitumor, antiinflammatory, and antiviral activities.

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Year:  2002        PMID： 12054973     DOI： 10.1021/jo025652f

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  7 in total

1.  Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration.

Authors:  Erik S Musiek; Rebecca S Breeding; Ginger L Milne; Giuseppe Zanoni; Jason D Morrow; Bethann McLaughlin
Journal:  J Neurochem       Date:  2006-04-21       Impact factor: 5.372

2.  The fatty acid oxidation product 15-A3t-isoprostane is a potent inhibitor of NFκB transcription and macrophage transformation.

Authors:  Joshua D Brooks; Erik S Musiek; Tyler R Koestner; Jeannette N Stankowski; Jocelyn R Howard; Enrico M Brunoldi; Alessio Porta; Giuseppe Zanoni; Giovanni Vidari; Jason D Morrow; Ginger L Milne; BethAnn McLaughlin
Journal:  J Neurochem       Date:  2011-09-23       Impact factor: 5.372

Review 3.  Recent advances in the biochemistry and clinical relevance of the isoprostane pathway.

Authors:  Erik S Musiek; Huiyong Yin; Ginger L Milne; Jason D Morrow
Journal:  Lipids       Date:  2005-10       Impact factor: 1.880

Review 4.  Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity.

Authors:  Erik S Musiek; Ginger L Milne; BethAnn McLaughlin; Jason D Morrow
Journal:  Brain Pathol       Date:  2005-04       Impact factor: 6.508

Review 5.  Electrophilic cyclopentenone isoprostanes in neurodegeneration.

Authors:  Erik S Musiek; Bethann McLaughlin; Jason D Morrow
Journal:  J Mol Neurosci       Date:  2007-09       Impact factor: 3.444

6.  Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.

Authors:  Anna-Liisa Levonen; Aimee Landar; Anup Ramachandran; Erin K Ceaser; Dale A Dickinson; Giuseppe Zanoni; Jason D Morrow; Victor M Darley-Usmar
Journal:  Biochem J       Date:  2004-03-01       Impact factor: 3.857

Review 7.  Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder.

Authors:  Cinzia Signorini; Claudio De Felice; Thierry Durand; Camille Oger; Jean-Marie Galano; Silvia Leoncini; Alessandra Pecorelli; Giuseppe Valacchi; Lucia Ciccoli; Joussef Hayek
Journal:  Oxid Med Cell Longev       Date:  2013-06-13       Impact factor: 6.543
  7 in total

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