Literature DB >> 12054345

Human anti-rhesus D IgG1 antibody produced in transgenic plants.

Thomas Bouquin1, Mads Thomsen, Leif Kofoed Nielsen, Trine Hefsgaard Green, John Mundy, Morten Hanefeld Dziegiel.   

Abstract

Transgenic plants represent an alternative to cell culture systems for producing cheap and safe antibodies for diagnostic and therapeutic use. To evaluate the functional properties of a 'plantibody', we generated transgenic Arabidopsis plants expressing full-length human IgG1 against the Rhesus D antigen, which is responsible for alloimmunization of RhD- mothers carrying an RhD+ fetus. Anti-RhD extracted from plants specifically reacted with RhD+ cells in antiglobulin technique, and elicited a respiratory burst in human peripheral blood mononuclear cells. Plant-derived antibody had equivalent properties to CHO cell-produced anti-RhD antibody, indicating its potential usefulness in diagnostic and therapeutic programs.

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Year:  2002        PMID： 12054345     DOI： 10.1023/a:1015226418688

Source DB:  PubMed          Journal:  Transgenic Res        ISSN： 0962-8819            Impact factor:   2.788


  32 in total

1.  Gene silencing results in instability of antibody production in transgenic plants.

Authors:  M De Neve; S De Buck; C De Wilde; H Van Houdt; I Strobbe; A Jacobs; A Depicker
Journal:  Mol Gen Genet       Date:  1999-01

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Journal:  Clin Lab Haematol       Date:  1988

3.  Stable expression of human beta1,4-galactosyltransferase in plant cells modifies N-linked glycosylation patterns.

Authors:  N Q Palacpac; S Yoshida; H Sakai; Y Kimura; K Fujiyama; T Yoshida; T Seki
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-13       Impact factor: 11.205

4.  N-glycans harboring the Lewis a epitope are expressed at the surface of plant cells.

Authors:  A C Fitchette-Lainé; V Gomord; M Cabanes; J C Michalski; M Saint Macary; B Foucher; B Cavelier; C Hawes; P Lerouge; L Faye
Journal:  Plant J       Date:  1997-12       Impact factor: 6.417

5.  Isolation of a mutant Arabidopsis plant that lacks N-acetyl glucosaminyl transferase I and is unable to synthesize Golgi-modified complex N-linked glycans.

Authors:  A von Schaewen; A Sturm; J O'Neill; M J Chrispeels
Journal:  Plant Physiol       Date:  1993-08       Impact factor: 8.340

6.  A new variant of Creutzfeldt-Jakob disease in the UK.

Authors:  R G Will; J W Ironside; M Zeidler; S N Cousens; K Estibeiro; A Alperovitch; S Poser; M Pocchiari; A Hofman; P G Smith
Journal:  Lancet       Date:  1996-04-06       Impact factor: 79.321

7.  Human Rh D monoclonal antibodies (BRAD-3 and BRAD-5) cause accelerated clearance of Rh D+ red blood cells and suppression of Rh D immunization in Rh D- volunteers.

Authors:  B M Kumpel; M J Goodrick; D H Pamphilon; I D Fraser; G D Poole; C Morse; G R Standen; G E Chapman; D P Thomas; D J Anstee
Journal:  Blood       Date:  1995-09-01       Impact factor: 22.113

8.  Evaluation of immunoglobulins from plant cells.

Authors:  M B Hein; Y Tang; D A McLeod; K D Janda; A Hiatt
Journal:  Biotechnol Prog       Date:  1991 Sep-Oct

9.  Correct glycosylation, Golgi-processing, and targeting to protein bodies of the vacuolar protein phytohemagglutinin in transgenic tobacco.

Authors:  A Sturm; T A Voelker; E M Herman; M J Chrispeels
Journal:  Planta       Date:  1988-08       Impact factor: 4.116

Review 10.  Molecular farming of pharmaceutical proteins.

Authors:  R Fischer; N Emans
Journal:  Transgenic Res       Date:  2000       Impact factor: 3.145
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  4 in total

1.  Stable Expression of Adalimumab in Nicotiana tabacum.

Authors:  Tzvi Zvirin; Lena Magrisso; Amit Yaari; Oded Shoseyov
Journal:  Mol Biotechnol       Date:  2018-06       Impact factor: 2.695

2.  Function and glycosylation of plant-derived antiviral monoclonal antibody.

Authors:  Kisung Ko; Yoram Tekoah; Pauline M Rudd; David J Harvey; Raymond A Dwek; Sergei Spitsin; Cathleen A Hanlon; Charles Rupprecht; Bernhard Dietzschold; Maxim Golovkin; Hilary Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-10       Impact factor: 11.205

3.  Cell engineering and molecular pharming for biopharmaceuticals.

Authors:  M A Abdullah; Anisa Ur Rahmah; A J Sinskey; C K Rha
Journal:  Open Med Chem J       Date:  2008-05-14

Review 4.  Antibody manufacture in transgenic animals and comparisons with other systems.

Authors:  Louis Marie Houdebine
Journal:  Curr Opin Biotechnol       Date:  2002-12       Impact factor: 9.740
  4 in total

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