Literature DB >> 120542

Protection by 4-amino-hex-5-enoic acid (gamma-vinyl GABA) and hypobaric hypoxia against kainic acid neurotoxicity.

P M Lenicque, J Wepierre, Y Cohen.   

Abstract

The behavioral effects following IP injection of kainic acid in rats could be cancelled with hypobaric hypoxia (8% O2 corresponding to 7000 m altitude) or with IP injections of 7-amino-hex-5-enoic acid at a dose of 0.9 g/kg-1. This protection may result from increased accumulations of GABA in brain tissues.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 120542     DOI： 10.1007/bf00431989

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  4 in total

1.  The log likelihood ratio test (the G-test); methods and tables for tests of heterogeneity in contingency tables.

Authors:  B WOOLF
Journal:  Ann Hum Genet       Date:  1957-06       Impact factor: 1.670

2.  [Contents of rabbit brains of gamma-amino butyric acid and ammonia after hypoxia and ischaemia (author's transl)].

Authors:  W Thorn; T Grieshaber; H Junge
Journal:  Pflugers Arch       Date:  1973       Impact factor: 3.657

3.  Effects of anaesthetics and anticonvulsants on the action of kainic acid in the rat hippocampus.

Authors:  R Zaczek; M F Nelson; J T Coyle
Journal:  Eur J Pharmacol       Date:  1978-12-01       Impact factor: 4.432

4.  gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice.

Authors:  M J Jung; B Lippert; B W Metcalf; P Böhlen; P J Schechter
Journal:  J Neurochem       Date:  1977-11       Impact factor: 5.372
  4 in total
  2 in total

1.  Proceedings of the British Pharmacological Society. 17th-19th December, 1979: University of London (Institute of Education).

Authors: 
Journal:  Br J Pharmacol       Date:  1980-06       Impact factor: 8.739

2.  The role of monoamines in the behavioural effects of kainic acid in rats.

Authors:  P M Lenicque; J Wepierre; Y Cohen
Journal:  J Neural Transm       Date:  1981       Impact factor: 3.575
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.