Literature DB >> 12054064

Epitope identification and vaccine design for cancer immunotherapy.

Alessandro Sette1, Elissa Keogh, Glenn Ishioka, John Sidney, Shabnam Tangri, Brian Livingston, Denise McKinney, Mark Newman, Robert Chesnut, John Fikes.   

Abstract

The development of processes for engineering multi-epitope vaccines based on the identification and selection of epitope packages, along with vaccine design optimization using epitope placements and spacers to optimize processing efficacy, are reviewed. The Epimmune Inc epitope identification process has been applied to numerous cancer types, but also applies to infectious diseases. Epitope-analog efforts in novel vaccine design have also been explored and their uses in prophylactic and therapeutic applications are eagerly anticipated.

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Year:  2002        PMID： 12054064

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  9 in total

Review 1.  Understanding the focused CD4 T cell response to antigen and pathogenic organisms.

Authors:  Jason M Weaver; Andrea J Sant
Journal:  Immunol Res       Date:  2009-02-07       Impact factor: 2.829

Review 2.  The sentinel within: exploiting the immune system for cancer biomarkers.

Authors:  Karen S Anderson; Joshua LaBaer
Journal:  J Proteome Res       Date:  2005 Jul-Aug       Impact factor: 4.466

3.  A multi-epitope vaccine CTB-UE relieves Helicobacter pylori-induced gastric inflammatory reaction via up-regulating microRNA-155 to inhibit Th17 response in C57/BL6 mice model.

Authors:  Xiaobo Lv; Hui Song; Jue Yang; Tong Li; Tao Xi; Yingying Xing
Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

Review 4.  Towards a rational design of an asymptomatic clinical herpes vaccine: the old, the new, and the unknown.

Authors:  Aziz Alami Chentoufi; Elizabeth Kritzer; David M Yu; Anthony B Nesburn; Lbachir Benmohamed
Journal:  Clin Dev Immunol       Date:  2012-03-26

5.  Computational prediction of immunodominant antigenic regions & potential protective epitopes for dengue vaccination.

Authors:  Karthikeyan Muthusamy; Krishnasamy Gopinath; Dharmalingam Nandhini
Journal:  Indian J Med Res       Date:  2016-10       Impact factor: 2.375

6.  The average IFN-γ secreting capacity of specific CD8(+) T cells is compromised while increasing copies of a single T cell epitope encoded by DNA vaccine.

Authors:  Yanmin Wan; Jing Wang; Haizhu Zhou; Zhidong Hu; Xiaonan Ren; Jianqing Xu
Journal:  Clin Dev Immunol       Date:  2012-11-01

7.  An efficient T-cell epitope discovery strategy using in silico prediction and the iTopia assay platform.

Authors:  Arthur Fridman; Adam C Finnefrock; Daniela Peruzzi; Irene Pak; Nicola La Monica; Ansuman Bagchi; Danilo R Casimiro; Gennaro Ciliberto; Luigi Aurisicchio
Journal:  Oncoimmunology       Date:  2012-11-01       Impact factor: 8.110

8.  Ranking of binding and nonbinding peptides to MHC class I molecules using inverse folding approach: implications for vaccine design.

Authors:  Satarudra Prakash Singh; Bhartendu Nath Mishra
Journal:  Bioinformation       Date:  2008-10-24

9.  Recombinant tandem multi-linear neutralizing epitopes of human enterovirus 71 elicited protective immunity in mice.

Authors:  Yue-Xiang Li; Hui Zhao; Rui-Yuan Cao; Yong-Qiang Deng; Jian-Feng Han; Shun-Ya Zhu; Jie Ma; Long Liu; E-De Qin; Cheng-Feng Qin
Journal:  Virol J       Date:  2014-05-06       Impact factor: 4.099
  9 in total

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