Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.

Literature DB >> 12052918

Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.

Lawrence Steinman¹, Roland Martin, Claude Bernard, Paul Conlon, Jorge R Oksenberg.

Abstract

Recent technological breakthroughs allowing for large-scale analysis of gene transcripts and large-scale monitoring of the immune response with protein chips are revealing new participants in the pathogenesis of multiple sclerosis. Some of these participants may be useful targets for therapy.

Entities: Disease Species

Mesh：

Substances：
Inflammation Mediators

Year: 2002 PMID： 12052918 DOI： 10.1146/annurev.neuro.25.112701.142913

Source DB: PubMed Journal: Annu Rev Neurosci ISSN： 0147-006X Impact factor: 12.449

Keyword Cloud
Cited

75 in total

1. Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in mice.

Authors: Run-Zhi Zhu; Di Xiang; Chao Xie; Jing-Jing Li; Jian-Jun Hu; Hong-Lin He; Yun-Sheng Yuan; Jin Gao; Wei Han; Yan Yu
Journal: World J Gastroenterol Date: 2010-06-14 Impact factor: 5.742

2. The intricate interplay among body weight, stress, and the immune response to friend or foe.

Authors: Lawrence Steinman; Paul Conlon; Rich Maki; Alan Foster
Journal: J Clin Invest Date: 2003-01 Impact factor: 14.808

3. Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.

Authors: Rosetta Pedotti; Jason J DeVoss; Sawsan Youssef; Dennis Mitchell; Jochen Wedemeyer; Rami Madanat; Hideki Garren; Paulo Fontoura; Mindy Tsai; Stephen J Galli; Raymond A Sobel; Lawrence Steinman
Journal: Proc Natl Acad Sci U S A Date: 2003-02-07 Impact factor: 11.205

9. Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders.

Authors: Thomas Stahnke; Christine Stadelmann; Anne Netzler; Wolfgang Brück; Christiane Richter-Landsberg
Journal: J Mol Neurosci Date: 2007 Impact factor: 3.444

Review 10. Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists.

Authors: Ramya Kapadia; Jae-Hyuk Yi; Raghu Vemuganti
Journal: Front Biosci Date: 2008-01-01

Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.

1. Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in mice.

2. The intricate interplay among body weight, stress, and the immune response to friend or foe.

3. Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.

4. Virus persistence in an animal model of multiple sclerosis requires virion attachment to sialic acid coreceptors.

Review 5. What do we know about the mechanism of action of disease-modifying treatments in MS?

6. IL-7Rα confers susceptibility to experimental autoimmune encephalomyelitis.

7. Peroxisome proliferator activated receptor-γ and traumatic brain injury.

Review 8. Targeting the B7 family of co-stimulatory molecules: successes and challenges.

9. Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders.

Review 10. Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists.