Literature DB >> 12050432

2-(3-tert-Butyldimethylsiloxy-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)indole.

Mallinath B Hadimani1, Raymond J Kessler, Jason A Kautz, Anjan Ghatak, Anupama R Shirali, Heather O'Dell, Charles M Garner, Kevin G Pinney.   

Abstract

In the crystal structure of the title compound, C(32)H(39)NO(7)Si, all geometric parameters fall within experimental error of expected values. The analysis of molecular-packing plots reveals an infinite two-dimensional linear array running parallel to the b axis, formed by one N[bond]H...O intermolecular hydrogen-bonding interaction. Several potential C[bond]H...O interactions are also present.

Entities:  

Year:  2002        PMID： 12050432     DOI： 10.1107/s0108270102003669

Source DB:  PubMed          Journal:  Acta Crystallogr C        ISSN： 0108-2701            Impact factor:   1.172


  5 in total

1.  Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006).

Authors:  Matthew T Macdonough; Tracy E Strecker; Ernest Hamel; John J Hall; David J Chaplin; Mary Lynn Trawick; Kevin G Pinney
Journal:  Bioorg Med Chem       Date:  2013-07-23       Impact factor: 3.641

2.  Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.

Authors:  Mallinath B Hadimani; Matthew T Macdonough; Anjan Ghatak; Tracy E Strecker; Ramona Lopez; Madhavi Sriram; Benson L Nguyen; John J Hall; Raymond J Kessler; Anupama R Shirali; Li Liu; Charles M Garner; George R Pettit; Ernest Hamel; David J Chaplin; Ralph P Mason; Mary Lynn Trawick; Kevin G Pinney
Journal:  J Nat Prod       Date:  2013-09-09       Impact factor: 4.050

3.  Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents.

Authors:  Rajendra P Tanpure; Amanda R Harkrider; Tracy E Strecker; Ernest Hamel; Mary Lynn Trawick; Kevin G Pinney
Journal:  Bioorg Med Chem       Date:  2009-08-12       Impact factor: 3.641

4.  Mechanistic Considerations in the Synthesis of 2-Aryl-Indole Analogues under Bischler-Mohlau Conditions.

Authors:  Matthew T MacDonough; Zhe Shi; Kevin G Pinney
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

5.  Crystal structures of four indole derivatives with a phenyl substituent at the 2-position and a carbonyl group at the 3-position: the C(6) N-H⋯O chain remains the same, but the weak reinforcing inter-actions are different.

Authors:  Jamie R Kerr; Laurent Trembleau; John M D Storey; James L Wardell; William T A Harrison
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-02-20
  5 in total

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