Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.

Literature DB >> 12050398

C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.

Carmen P Alvarez¹, Fátima Lasala, Jaime Carrillo, Oscar Muñiz, Angel L Corbí, Rafael Delgado.

Abstract

Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12050398 PMCID： PMC136246 DOI： 10.1128/jvi.76.13.6841-6844.2002

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

17 in total

1. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses.

Authors: T B Geijtenbeek; R Torensma; S J van Vliet; G C van Duijnhoven; G J Adema; Y van Kooyk; C G Figdor
Journal: Cell Date: 2000-03-03 Impact factor: 41.582

2. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.

Authors: T B Geijtenbeek; D S Kwon; R Torensma; S J van Vliet; G C van Duijnhoven; J Middel; I L Cornelissen; H S Nottet; V N KewalRamani; D R Littman; C G Figdor; Y van Kooyk
Journal: Cell Date: 2000-03-03 Impact factor: 41.582

3. Generation of retroviral vector for clinical studies using transient transfection.

Authors: S Yang; R Delgado; S R King; C Woffendin; C S Barker; Z Y Yang; L Xu; G P Nolan; G J Nabel
Journal: Hum Gene Ther Date: 1999-01-01 Impact factor: 5.695

4. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues.

Authors: S D Weitman; R H Lark; L R Coney; D W Fort; V Frasca; V R Zurawski; B A Kamen
Journal: Cancer Res Date: 1992-06-15 Impact factor: 12.701

5. Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins.

Authors: Z Yang; R Delgado; L Xu; R F Todd; E G Nabel; A Sanchez; G J Nabel
Journal: Science Date: 1998-02-13 Impact factor: 47.728

6. Similar structural models of the transmembrane proteins of Ebola and avian sarcoma viruses.

Authors: W R Gallaher
Journal: Cell Date: 1996-05-17 Impact factor: 41.582

7. Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines.

Authors: R J Wool-Lewis; P Bates
Journal: J Virol Date: 1998-04 Impact factor: 5.103

8. Pathogenesis of experimental Ebola virus infection in guinea pigs.

Authors: B M Connolly; K E Steele; K J Davis; T W Geisbert; W M Kell; N K Jaax; P B Jahrling
Journal: J Infect Dis Date: 1999-02 Impact factor: 5.226

9. Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.

Authors: B M Curtis; S Scharnowske; A J Watson
Journal: Proc Natl Acad Sci U S A Date: 1992-09-01 Impact factor: 11.205

10. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.

Authors: A A Bashirova; T B Geijtenbeek; G C van Duijnhoven; S J van Vliet; J B Eilering; M P Martin; L Wu; T D Martin; N Viebig; P A Knolle; V N KewalRamani; Y van Kooyk; M Carrington
Journal: J Exp Med Date: 2001-03-19 Impact factor: 14.307

277 in total

1. Less is more: Ebola virus surface glycoprotein expression levels regulate virus production and infectivity.

Authors: Gopi S Mohan; Ling Ye; Wenfang Li; Ana Monteiro; Xiaoqian Lin; Bishu Sapkota; Brian P Pollack; Richard W Compans; Chinglai Yang
Journal: J Virol Date: 2014-11-12 Impact factor: 5.103

2. Inhibition of human immunodeficiency virus type 1 Env-mediated fusion by DC-SIGN.

Authors: Cinzia Nobile; Arnaud Moris; Françoise Porrot; Nathalie Sol-Foulon; Olivier Schwartz
Journal: J Virol Date: 2003-05 Impact factor: 5.103

Review 3. Dangerous liaisons at the virological synapse.

Authors: Vincent Piguet; Quentin Sattentau
Journal: J Clin Invest Date: 2004-09 Impact factor: 14.808

Review 4. DC-SIGN: binding receptor for HCV?

Authors: Zhi-Hua Feng; Quan-Chu Wang; Qing-He Nie; Zhan-Sheng Jia; Yong-Xin Zhou
Journal: World J Gastroenterol Date: 2004-04-01 Impact factor: 5.742

5. Specific interaction of feline immunodeficiency virus surface glycoprotein with human DC-SIGN.

Authors: Aymeric de Parseval; Stephen V Su; John H Elder; Benhur Lee
Journal: J Virol Date: 2004-03 Impact factor: 5.103

6. DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus.

Authors: Andrea Marzi; Thomas Gramberg; Graham Simmons; Peggy Möller; Andrew J Rennekamp; Mandy Krumbiegel; Martina Geier; Jutta Eisemann; Nadine Turza; Bertrand Saunier; Alexander Steinkasserer; Stephan Becker; Paul Bates; Heike Hofmann; Stefan Pöhlmann
Journal: J Virol Date: 2004-11 Impact factor: 5.103

7. Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies.

Authors: Lakshmanan Ganesh; Kwanyee Leung; Karin Loré; Reuven Levin; Amos Panet; Owen Schwartz; Richard A Koup; Gary J Nabel
Journal: J Virol Date: 2004-11 Impact factor: 5.103