| Literature DB >> 12049942 |
Michihiro Mieda1, Masashi Yanagisawa.
Abstract
Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.Entities:
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Year: 2002 PMID: 12049942 DOI: 10.1016/s0959-4388(02)00331-8
Source DB: PubMed Journal: Curr Opin Neurobiol ISSN: 0959-4388 Impact factor: 6.627