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Literature DB >> 12049811

Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma.

Shoji Yamazaki¹, Tatuo Morita, Hitoshi Endo, Toshiro Hamamoto, Masaki Baba, Yoshiko Joichi, Sanae Kaneko, Yoshihito Okada, Toru Okuyama, Hoyoku Nishino, Akihiko Tokue.

Abstract

Isoliquiritigenin is a chalcone isolated from licorice and shallots. The ability of isoliquiritigenin to suppress metastasis was examined in a pulmonary metastasis model of mouse renal cell carcinoma. Isoliquiritigenin significantly reduced pulmonary metastasis, without any weight loss or leukocytopenia. Isoliquiritigenin suppressed in vitro proliferation of carcinoma cells, potentiated nitric oxide production by lipopolysaccharide-stimulated macrophages, and facilitated cytotoxicity of splenic lymphocytes in vitro. These findings suggest activation of macrophages, activation of cytotoxicity of lymphocytes, and direct cytotoxicity as possible mechanisms of metastasis suppression by isoliquiritigenin. In addition, isoliquiritigenin prevented severe leukocytopenia caused by administration of 5-fluorouracil.

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Year: 2002 PMID： 12049811 DOI： 10.1016/s0304-3835(02)00113-1

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

28 in total

1. Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR.

Authors: Sung Keun Jung; Mee-Hyun Lee; Do Young Lim; Jong Eun Kim; Puja Singh; Sung-Young Lee; Chul-Ho Jeong; Tae-Gyu Lim; Hanyong Chen; Young-In Chi; Joydeb Kumar Kundu; Nam Hyouck Lee; Charles C Lee; Yong-Yeon Cho; Ann M Bode; Ki Won Lee; Zigang Dong
Journal: J Biol Chem Date: 2014-11-03 Impact factor: 5.157

2. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling.

Authors: Xiangzheng Chen; Yangping Wu; Yangfu Jiang; Yan Zhou; Yuxi Wang; Yuqin Yao; Cheng Yi; Lantu Gou; Jinliang Yang
Journal: J Mol Med (Berl) Date: 2012-05-31 Impact factor: 4.599

3. Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells.

Authors: Tatsushi Yoshida; Mano Horinaka; Mami Takara; Mayuko Tsuchihashi; Nobuhiro Mukai; Miki Wakada; Toshiyuki Sakai
Journal: Environ Health Prev Med Date: 2008-07-31 Impact factor: 3.674

Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma.

1. Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR.

2. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling.

3. Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells.

4. Dietary chalcones with chemopreventive and chemotherapeutic potential.

Review 5. Quinone reductase induction as a biomarker for cancer chemoprevention.

6. Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies.

7. Sites of alkylation of human Keap1 by natural chemoprevention agents.

8. Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien Liquid.

9. (E)-1-(6-Chloro-2-methyl-4-phenyl-3-quinol-yl)-3-(4-ethoxy-phen-yl)prop-2-en-1-one.

10. 1-(6-Chloro-2-methyl-4-phenyl-3-quinol-yl)ethanone.