Literature DB >> 12049515

Synthesis of cyclosporin A-derived affinity reagents by olefin metathesis.

Jason A Smulik1, Steven T Diver, Fan Pan, Jun O Liu.   

Abstract

[reaction: see text] New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.

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Year:  2002        PMID： 12049515     DOI： 10.1021/ol0258987

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Synthesis, characterization, and utility of thermoresponsive natural/unnatural product macroligands for affinity chromatography.

Authors:  Min Zhou; Ananthapadmanab Sivaramakrishnan; Krishan Ponnamperuma; Woon-Kai Low; Chunmei Li; Jun O Liu; David E Bergbreiter; Daniel Romo
Journal:  Org Lett       Date:  2006-11-09       Impact factor: 6.005

2.  Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.

Authors:  Justin Warne; Gareth Pryce; Julia M Hill; Xiao Shi; Felicia Lennerås; Fabiola Puentes; Maarten Kip; Laura Hilditch; Paul Walker; Michela I Simone; A W Edith Chan; Greg J Towers; Alun R Coker; Michael R Duchen; Gyorgy Szabadkai; David Baker; David L Selwood
Journal:  J Biol Chem       Date:  2015-12-17       Impact factor: 5.157
  2 in total

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