V Jay1, M Ho, F Chan, D Malkin. 1. Department of Pathology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.
Abstract
OBJECTIVE: To evaluate choroid plexus neoplasms for p53 expression. CASE MATERIAL: We studied 10 choroid plexus tumors (four papillomas and six carcinomas) by immunohistochemistry using the DO7 anti-p53 monoclonal antibody. RESULTS: Three of four choroid plexus papillomas demonstrated no staining. Scattered nuclear and rare cytoplasmic positivity was present in one papilloma, which showed foci of increased mitotic activity (labeling index 2.5%). Six of six carcinomas were immunoreactive for p53, and three cases had labeling indexes of over 70%. All immunopositive choroid plexus tumors (7/7) exhibited nuclear staining. Punctate cytoplasmic positivity was identified in 5 of 7 cases. CONCLUSION: Our study suggests that altered p53 expression is detectable by immunohistochemistry in choroid plexus neoplasms and is consistently present in choroid plexus carcinomas.
OBJECTIVE: To evaluate choroid plexus neoplasms for p53 expression. CASE MATERIAL: We studied 10 choroid plexus tumors (four papillomas and six carcinomas) by immunohistochemistry using the DO7 anti-p53 monoclonal antibody. RESULTS: Three of four choroid plexus papillomas demonstrated no staining. Scattered nuclear and rare cytoplasmic positivity was present in one papilloma, which showed foci of increased mitotic activity (labeling index 2.5%). Six of six carcinomas were immunoreactive for p53, and three cases had labeling indexes of over 70%. All immunopositive choroid plexus tumors (7/7) exhibited nuclear staining. Punctate cytoplasmic positivity was identified in 5 of 7 cases. CONCLUSION: Our study suggests that altered p53 expression is detectable by immunohistochemistry in choroid plexus neoplasms and is consistently present in choroid plexus carcinomas.
Authors: Martin Hasselblatt; Sonja Mertsch; Björn Koos; Barbara Riesmeier; Heike Stegemann; Astrid Jeibmann; Manuel Tomm; Nicole Schmitz; Brigitte Wrede; Johannes E Wolff; Wei Zheng; Werner Paulus Journal: Cancer Res Date: 2009-03-10 Impact factor: 12.701
Authors: Michael Safaee; Michael C Oh; Orin Bloch; Matthew Z Sun; Gurvinder Kaur; Kurtis I Auguste; Tarik Tihan; Andrew T Parsa Journal: Neuro Oncol Date: 2012-11-21 Impact factor: 12.300