Literature DB >> 1204805

Effect of progesterone on human corticosteroid 21-hydroxylation.

R H Wickramasinghe, G T Bryan.   

Abstract

Progesterone inhibits the 21-hydroxylation of 17alpha-hydroxyprogesterone by human adrenal cortex microsomes. The possible light this finding may shed on the genetic condition, the 'adrenogenital syndrome' is discussed. Km and Vmax data for the above hydroxylation reaction are given.

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Year:  1975        PMID： 1204805     DOI： 10.1007/bf01945831

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

Review 1.  Biological aspects of cytochrome P450 and associated hydroxylation reactions.

Authors:  R H Wickramasinghe
Journal:  Enzyme       Date:  1975

2.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

3.  IMPAIRED ALDOSTERONE PRODUCTION IN "SALT-LOSING" CONGENITAL ADRENAL HYPERPLASIA.

Authors:  G T BRYAN; B KLIMAN; F C BARTTER
Journal:  J Clin Invest       Date:  1965-06       Impact factor: 14.808

4.  Significance of the steroid-induced type I spectral change in steroid C-21 hydroxylase system of bovine adrenocortical microsomes.

Authors:  S Narasimhulu
Journal:  Arch Biochem Biophys       Date:  1971-12       Impact factor: 4.013

5.  Salt-losers and non salt-losers in congenital adrenal hyperplasia.

Authors:  F C Bartter
Journal:  Arch Dis Child       Date:  1969-02       Impact factor: 3.791

6.  Adrenodoxin reductase, the flavoprotein component of adrenal mitochondrial steroid hydroxylases. I. Purification and certain characteristics.

Authors:  R H Wickramasinghe
Journal:  Int J Pept Protein Res       Date:  1974
  6 in total

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