OBJECTIVES: To investigate the relationship between amyotrophic lateral sclerosis (ALS) and cognitive function by means of oddball event-related potentials (ERPs) and to determine the usefulness of this methodology in the cognitive status assessment of physically disabled patients. METHODS: Visual and auditory oddball ERPs were recorded in 16 consecutive sporadic ALS patients. A comprehensive battery of neuropsychological (NP) tests assessed intelligence, executive functions, attention, memory, word fluency, visuo-motor and visual-constructive skills. RESULTS: All patients performed visual and auditory ERPs and 75% of cases showed abnormal N200 and/or P300 waves. Ten patients (62.5%) carried out the entire psychometric evaluation with significant impairment on tests of executive function and attention. A significant correlation between delayed visual (P<0.04) and auditory (P<0.04) P300 latency and impaired NP tests was found. CONCLUSIONS: In agreement with literature data, our findings confirm the hypothesis of cognitive impairment in ALS patients especially on attention and executive functions suggesting a more extensive degeneration beyond the motor areas. ALS causes severe physical disabilities and such a condition may interfere with NP testing. Thus, the P300 seems to be a useful tool for the assessment of cognition and attention when severe physical deficits are present.
OBJECTIVES: To investigate the relationship between amyotrophic lateral sclerosis (ALS) and cognitive function by means of oddball event-related potentials (ERPs) and to determine the usefulness of this methodology in the cognitive status assessment of physically disabled patients. METHODS:Visual and auditory oddball ERPs were recorded in 16 consecutive sporadic ALSpatients. A comprehensive battery of neuropsychological (NP) tests assessed intelligence, executive functions, attention, memory, word fluency, visuo-motor and visual-constructive skills. RESULTS: All patients performed visual and auditory ERPs and 75% of cases showed abnormal N200 and/or P300 waves. Ten patients (62.5%) carried out the entire psychometric evaluation with significant impairment on tests of executive function and attention. A significant correlation between delayed visual (P<0.04) and auditory (P<0.04) P300 latency and impaired NP tests was found. CONCLUSIONS: In agreement with literature data, our findings confirm the hypothesis of cognitive impairment in ALSpatients especially on attention and executive functions suggesting a more extensive degeneration beyond the motor areas. ALS causes severe physical disabilities and such a condition may interfere with NP testing. Thus, the P300 seems to be a useful tool for the assessment of cognition and attention when severe physical deficits are present.
Authors: Lynn M McCane; Susan M Heckman; Dennis J McFarland; George Townsend; Joseph N Mak; Eric W Sellers; Debra Zeitlin; Laura M Tenteromano; Jonathan R Wolpaw; Theresa M Vaughan Journal: Clin Neurophysiol Date: 2015-02-07 Impact factor: 3.708
Authors: Pietro Cipresso; Laura Carelli; Federica Solca; Daniela Meazzi; Paolo Meriggi; Barbara Poletti; Dorothée Lulé; Albert C Ludolph; Vincenzo Silani; Giuseppe Riva Journal: Brain Behav Date: 2012-07 Impact factor: 2.708
Authors: Jana I Münßinger; Sebastian Halder; Sonja C Kleih; Adrian Furdea; Valerio Raco; Adi Hösle; Andrea Kübler Journal: Front Neurosci Date: 2010-11-22 Impact factor: 4.677
Authors: Sebastian Halder; Carolin Anne Ruf; Adrian Furdea; Emanuele Pasqualotto; Daniele De Massari; Linda van der Heiden; Martin Bogdan; Wolfgang Rosenstiel; Niels Birbaumer; Andrea Kübler; Tamara Matuz Journal: PLoS One Date: 2013-10-18 Impact factor: 3.240