Literature DB >> 1204787

Pathological changes in the liver of mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin.

G Jones, J B Greig.   

Abstract

In C57BL/6 mice a single oral dose of 2,3,7,8-tetrachlorodibenzodioxin (LD50 126 mug/kg) results in loss of body weight and death with an enlarged fatty liver after ca. 21 days. A progressive necrotic centrilobular liver lesion is also seen.

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Year:  1975        PMID： 1204787     DOI： 10.1007/bf01945801

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  POSSIBLE SYNTHESIS OF POLYRIBONUCLEOTIDES OF KNOWN BASE-TRIPLET SEQUENCES.

Authors:  R W MASTER
Journal:  Nature       Date:  1965-04-03       Impact factor: 49.962

2.  Adenosine triphosphatase in the microsomal fraction from rat brain.

Authors:  W N ALDRIDGE
Journal:  Biochem J       Date:  1962-06       Impact factor: 3.857

3.  [Occupational poisonings in the production of chlorphenol compounds].

Authors:  H BAUER; K H SCHULZ; U SPIEGELBERG
Journal:  Arch Gewerbepathol Gewerbehyg       Date:  1961

4.  A morphological study of the liver lesion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats.

Authors:  G Jones; W H Butler
Journal:  J Pathol       Date:  1974-02       Impact factor: 7.996

5.  Hepatic porphyria induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse.

Authors:  J A Goldstein; P Hickman; H Bergman; J G Vos
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1973-11

6.  Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors:  J B Greig; G Jones; W H Butler; J M Barnes
Journal:  Food Cosmet Toxicol       Date:  1973-08

7.  Studies of the chick edema disease. 9. Response of chicks fed or singly administered synthetic edema-producing compounds.

Authors:  D F Flick; D Firestone; G R Higginbotham
Journal:  Poult Sci       Date:  1972-11       Impact factor: 3.352

8.  A rapid and simple method for the determination of esterified fatty acids and for total fatty acids in blood.

Authors:  I STERN; B SHAPIRO
Journal:  J Clin Pathol       Date:  1953-05       Impact factor: 3.411

9.  Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on drug metabolism and hepatic microsomes of rats and mice.

Authors:  J B Greig; F De Matteis
Journal:  Environ Health Perspect       Date:  1973-09       Impact factor: 9.031
  9 in total
  5 in total

1.  Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.

Authors:  Kelly A Fader; Rance Nault; Mathew P Kirby; Gena Markous; Jason Matthews; Timothy R Zacharewski
Journal:  Toxicol Appl Pharmacol       Date:  2017-02-16       Impact factor: 4.219

2.  Pleiotropic effect of the gene hairless on hepatotoxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mice.

Authors:  J B Greig; J E Francis; S J Kay; T Lister; D E Ray; A A Seawright; A G Smith
Journal:  Arch Toxicol       Date:  1987-07       Impact factor: 5.153

3.  2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice.

Authors:  Russell R Fling; Claire M Doskey; Kelly A Fader; Rance Nault; Tim R Zacharewski
Journal:  Sci Rep       Date:  2020-09-09       Impact factor: 4.379

Review 4.  Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review.

Authors:  Raquel Cano; José L Pérez; Lissé Angarita Dávila; Ángel Ortega; Yosselin Gómez; Nereida Josefina Valero-Cedeño; Heliana Parra; Alexander Manzano; Teresa Isabel Véliz Castro; María P Díaz Albornoz; Gabriel Cano; Joselyn Rojas-Quintero; Maricarmen Chacín; Valmore Bermúdez
Journal:  Int J Mol Sci       Date:  2021-05-01       Impact factor: 5.923

5.  2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism.

Authors:  Kelly A Fader; Rance Nault; Chen Zhang; Kazuyoshi Kumagai; Jack R Harkema; Timothy R Zacharewski
Journal:  Sci Rep       Date:  2017-07-19       Impact factor: 4.379
  5 in total

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