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Literature DB >> 12047857

Hydrogels: from controlled release to pH-responsive drug delivery.

Piyush Gupta¹, Kavita Vermani, Sanjay Garg.

Abstract

Hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogels also show stimuli-responsive changes in their structural network and hence, the drug release. Because of large variations in physiological pH at various body sites in normal as well as pathological conditions, pH-responsive polymeric networks have been extensively studied. This review highlights the use of hydrogels (a class of polymeric systems) in controlled drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release.

Entities: Chemical

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Year: 2002 PMID： 12047857 DOI： 10.1016/s1359-6446(02)02255-9

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

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Cited

136 in total

1. Influence of environmental solution pH and microstructural parameters on mechanical behavior of amphoteric pH-sensitive hydrogels.

Authors: Huixian Yan; Bo Jin
Journal: Eur Phys J E Soft Matter Date: 2012-05-25 Impact factor: 1.890

2. Crosslinking of gelatin-based drug carriers by genipin induces changes in drug kinetic profiles in vitro.

Authors: Goutam Thakur; Analava Mitra; Dérick Rousseau; Amit Basak; Siddik Sarkar; Kunal Pal
Journal: J Mater Sci Mater Med Date: 2010-11-25 Impact factor: 3.896

3. Radiation preparation of L-arginine/acrylic acid hydrogel matrix patch for transdermal delivery of propranolol HCl in hypertensive rats.

Authors: Rasha R Radwan; Heba A Mohamed; H E Ali; Ghada A Mahmoud
Journal: Drug Deliv Transl Res Date: 2018-06 Impact factor: 4.617

4. Heat and mass transfer scale-up issues during freeze-drying, III: control and characterization of dryer differences via operational qualification tests.

Authors: S Rambhatla; S Tchessalov; Michael J Pikal
Journal: AAPS PharmSciTech Date: 2006-04-21 Impact factor: 3.246

5. Augmenting protein release from layer-by-layer functionalized agarose hydrogels.

Authors: Daniel Lynam; Chelsea Peterson; Ryan Maloney; Dena Shahriari; Alexa Garrison; Sara Saleh; Sumit Mehrotra; Christina Chan; Jeff Sakamoto
Journal: Carbohydr Polym Date: 2013-12-28 Impact factor: 9.381

Review 6. Programmable hydrogels.

Authors: Yong Wang
Journal: Biomaterials Date: 2018-03-05 Impact factor: 12.479

Hydrogels: from controlled release to pH-responsive drug delivery.

1. Influence of environmental solution pH and microstructural parameters on mechanical behavior of amphoteric pH-sensitive hydrogels.

2. Crosslinking of gelatin-based drug carriers by genipin induces changes in drug kinetic profiles in vitro.

3. Radiation preparation of L-arginine/acrylic acid hydrogel matrix patch for transdermal delivery of propranolol HCl in hypertensive rats.

4. Heat and mass transfer scale-up issues during freeze-drying, III: control and characterization of dryer differences via operational qualification tests.

5. Augmenting protein release from layer-by-layer functionalized agarose hydrogels.

Review 6. Programmable hydrogels.

7. Functional block copolymer nanoparticles: toward the next generation of delivery vehicles.

8. Clinical significance of three-dimensional printed biomaterials and biomedical devices.

9. Immobilization of Myoglobin from Horse Skeletal Muscle in Hydrophilic Polymer Networks.

Review 10. Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery.