| Literature DB >> 12046991 |
Nobuyuki Fukuishi1, Motoko Matsuhisa, Takeshi Shimono, Nobutoshi Murata, Mari Iwanaga, Hidenori Sagara, Nobuaki Matsui, Masaaki Akagi.
Abstract
The inhibitory effect of olopatadine, a new antiallergic drug, on antigen-induced eosinophil infiltration and its mechanisms were examined using the local sensitized rat allergic rhinitis model and isolated IL-5-stimulated rat peritoneal eosinophils. Olopatadine dose-dependently inhibited antigen-induced eosinophil infiltration in the nasal mucosa. Olopatadine dose-dependently repressed the IL-5-induced expressions of CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) on rat peritoneal eosinophils. However, olopatadine had no effect on IL-5-induced CD49d/CD29 (VLA-4) expression. These results suggest that olopatadine may inhibit antigen-induced eosinophil infiltration through repression of LFA-1 and Mac-1 expression.Entities:
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Year: 2002 PMID： 12046991 DOI： 10.1254/jjp.88.463
Source DB: PubMed Journal: Jpn J Pharmacol ISSN： 0021-5198