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Literature DB >> 1204692

An ultrastructural study of normal and injured hypoglossal nuclei after injection of horseradish peroxidase.

Abstract

The left hypoglossal nuclei of normal rats, and rats which had received left hypoglossal nerve axotomies 7-21 days previously, were studied by electron microscopy after injection of horseradish peroxidase as a marker of extracellular space and pinocytosis. Quantitative analysis showed that the number of pinocytotically-derived structures in presynaptic boutons was significantly increased in rats at 7, 14, and 21 days after axotomy when compared with normal rats. It was suggested that presynaptic boutons which became detached from injured neurones retracted by a membrane cycling mechanism involving pinocytotic uptake of bouton plasmalemma, without compensatory membrane production elsewhere. It was confirmed that the channels in the microglial cells communicated with the extracellular space.

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Year: 1975 PMID： 1204692 DOI： 10.1007/bf00234915

Source DB: PubMed Journal: Exp Brain Res ISSN： 0014-4819 Impact factor: 1.972

20 in total

1. A quantitative analysis of the response of presynaptic boutons to postsynaptic motor neuron axotomy.

Authors: B E Sumner
Journal: Exp Neurol Date: 1975-03 Impact factor: 5.330

2. Detachment of structurally intact nerve endings from chromatolytic neurones of rat superior cervical ganglion during the depression of synaptic transmission induced by post-ganglionic axotomy.

Authors: M R Matthews; V H Nelson
Journal: J Physiol Date: 1975-02 Impact factor: 5.182

6. Micropinocytotic origin of coated and smooth microvesicles ("synaptic vesicles") in neurosecretory terminals of posterior pituitary glands demonstrated by incorporation of horseradish peroxidase.

Authors: J Nagasawa; W W Douglas; R A Schulz
Journal: Nature Date: 1971-07-30 Impact factor: 49.962

7. An autoradiographic study of the incorporation of nucleic-acid precursors by neurones and glia during nerve regeneration.

Authors: W E Watson
Journal: J Physiol Date: 1965-10 Impact factor: 5.182

8. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.

Authors: R C Graham; M J Karnovsky
Journal: J Histochem Cytochem Date: 1966-04 Impact factor: 2.479

9. Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction.

Authors: J E Heuser; T S Reese
Journal: J Cell Biol Date: 1973-05 Impact factor: 10.539

10. Fine structure of nerve fibers and growth cones of isolated sympathetic neurons in culture.

Authors: M B Bunge
Journal: J Cell Biol Date: 1973-03 Impact factor: 10.539

4 in total

1. Ultrastructural responses of the hypoglossal nucleus to the presence in the tongue of botulinum toxin, a quantitative study.

Authors: B E Sumner
Journal: Exp Brain Res Date: 1977-11-24 Impact factor: 1.972

2. Membrane-associated adenosine triphosphatase in normal and injured hypoglossal nuclei.

Authors: B E Sumner
Journal: Exp Brain Res Date: 1978-10-13 Impact factor: 1.972

Review 3. Retrograde axonal and transsynaptic transport of macromolecules: physiological and pathophysiological importance.

Authors: M E Schwab; H Thoenen
Journal: Agents Actions Date: 1977-09

4. Quantitative ultrastructural observations on the inhibited recovery of the hypoglossal nucleus from the axotomy response when regeneration of the hypoglossal nerve is prevented.

Authors: B E Sumner
Journal: Exp Brain Res Date: 1976-09-24 Impact factor: 1.972