M Emre Atabek1, K Aydin, I Erkul. 1. Department of Pediatrics, Faculty of Medicine, Selçuk University, Konya, Turkey. eatabek@selcuk.edu.tr
Abstract
OBJECTIVE: To evaluate clinical experience of amitraz poisoning in children. METHODS: In this study, the clinical and laboratory features of amitraz poisoning in 14 children are presented and compared with previous studies. RESULTS: This study revealed that clinical manifestations of poisoning by oral and dermal routes appeared within 30-150 min, and that central nervous system (CNS) depression, which is the most important sign, improved within 6-24 hours and other signs within 24-72 hours. Unlike the findings in other studies, three severe cases in our study had reversible mydriasis and one of them required resuscitation because of cardiopulmonary arrest occurring as a result of serious respiratory depression. In addition, hepatic function test levels had increased in these three cases, and aspiration pneumonitis existed because of emesis in two of them. CONCLUSION: There is little information in the literature about dermal poisoning. The signs and symptoms of dermal poisoning were relatively mild compared with oral poisoning, and there were no topical signs. The classical signs of alpha2-adrenergic stimulation such as marked sinusal bradycardia and mydriasis as reported in many poisoning cases of animals have not been reported before our three severe cases among children.
OBJECTIVE: To evaluate clinical experience of amitraz poisoning in children. METHODS: In this study, the clinical and laboratory features of amitraz poisoning in 14 children are presented and compared with previous studies. RESULTS: This study revealed that clinical manifestations of poisoning by oral and dermal routes appeared within 30-150 min, and that central nervous system (CNS) depression, which is the most important sign, improved within 6-24 hours and other signs within 24-72 hours. Unlike the findings in other studies, three severe cases in our study had reversible mydriasis and one of them required resuscitation because of cardiopulmonary arrest occurring as a result of serious respiratory depression. In addition, hepatic function test levels had increased in these three cases, and aspiration pneumonitis existed because of emesis in two of them. CONCLUSION: There is little information in the literature about dermal poisoning. The signs and symptoms of dermal poisoning were relatively mild compared with oral poisoning, and there were no topical signs. The classical signs of alpha2-adrenergic stimulation such as marked sinusal bradycardia and mydriasis as reported in many poisoning cases of animals have not been reported before our three severe cases among children.
Authors: H M M T B Herath; S P Pahalagamage; Nilukshana Yogendranathan; M D M S Wijayabandara; Aruna Kulatunga Journal: BMC Pharmacol Toxicol Date: 2017-01-23 Impact factor: 2.483