| Literature DB >> 12045392 |
Dorte Holst1, Paul A Grimaldi.
Abstract
Obesity and lipoatrophy are major risks for insulin resistance, type 2 diabetes and cardiovascular diseases. The molecular links between adipocyte dysfunction and metabolic disorders were elusive until the discovery that adipose tissue operates as an endocrine organ and releases factors targeting a wide range of organs. This article attempts to review the more recent advances from research on the transcriptional control of adipogenesis and on new adipocyte-secreted proteins that have been proposed as molecular links between adipose tissue and insulin resistance.Entities:
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Year: 2002 PMID: 12045392 DOI: 10.1097/00041433-200206000-00002
Source DB: PubMed Journal: Curr Opin Lipidol ISSN: 0957-9672 Impact factor: 4.776