Literature DB >> 12045354

New synthetic route to granulatimide and its structural analogues.

Takuji Yoshida1, Masakazu Nishiyachi, Nobuyuki Nakashima, Masayuki Murase, Eiichi Kotani.   

Abstract

The Stille coupling reaction of stannylindole 12 with 4-iodoimidazole 13 (or 24) in the presence of PdCl(2)(PPh(3))(2) gave the corresponding indole-imidazole coupling product 14 (or 25), thereby affording a new synthetic approach to the alkaloid granulatimide (7), isolated from the Brazilian ascidian Didemnum granulatum, as well as its structural analogues, 10-methylgranulatimide (23), 17-methylgranulatimide (30), 10,17-dimethylgranulatimide (31).

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Year:  2002        PMID: 12045354     DOI: 10.1248/cpb.50.872

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  2 in total

1.  Facile synthesis of indole- or benzofuran-fused benzo[a]carbazole-1,4-diones using a tandem two-step reaction sequence.

Authors:  Shanghui Tu; Chunyong Ding; Wenxiang Hu; Fulong Li; Qizheng Yao; Ao Zhang
Journal:  Mol Divers       Date:  2010-03-14       Impact factor: 2.943

Review 2.  Marine pyrrolocarbazoles and analogues: synthesis and kinase inhibition.

Authors:  Sébastien Deslandes; Stefan Chassaing; Evelyne Delfourne
Journal:  Mar Drugs       Date:  2009-12-01       Impact factor: 5.118

  2 in total

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