Literature DB >> 12044971

Effects of IL6 and IL1beta on aFGF expression and excitotoxicity in NT2N cells.

Veronika Thorns1, Gerhard Franz Walter, Federico Licastro.   

Abstract

The interleukin-1beta (IL1beta) and interleukin-6 (IL6) have pro-inflammatory and neuroprotective functions and are elevated in many diseases of the brain. Here, mechanisms and effects of IL1beta and IL6 on neuronal survival after excitatory stimulation were investigated in vitro. IL6 upregulated the expression of the neuroprotective acidic fibroblast growth factor (aFGF) and reduced the glutamate-induced cytotoxicity. IL1beta treatment amplified the excitotoxic effects after 24 h, but longer treatment with IL1beta stimulated the neuronal release of IL6 resulting in increased levels of aFGF and a decreased excitotoxicity. These data suggest that (1) IL6 exerts protective functions by upregulating the expression of aFGF and (2) the IL6/IL1beta balance in the brain may regulate neuronal survival during neuropathological processes.

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Year:  2002        PMID： 12044971     DOI： 10.1016/s0165-5728(02)00072-3

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  7 in total

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Authors:  Jiyong Zhang; Grazyna B Sadowska; Xiaodi Chen; Seon Yeong Park; Jeong-Eun Kim; Courtney A Bodge; Erin Cummings; Yow-Pin Lim; Oleksandr Makeyev; Walter G Besio; John Gaitanis; William A Banks; Barbara S Stonestreet
Journal:  FASEB J       Date:  2015-01-21       Impact factor: 5.191

2.  Neutralizing anti-interleukin-1β antibodies modulate fetal blood-brain barrier function after ischemia.

Authors:  Xiaodi Chen; Grazyna B Sadowska; Jiyong Zhang; Jeong-Eun Kim; Erin E Cummings; Courtney A Bodge; Yow-Pin Lim; Oleksandr Makeyev; Walter G Besio; John Gaitanis; Steven W Threlkeld; William A Banks; Barbara S Stonestreet
Journal:  Neurobiol Dis       Date:  2014-09-26       Impact factor: 5.996

3.  Ontogeny and the effects of in utero brain ischemia on interleukin-1β and interleukin-6 protein expression in ovine cerebral cortex and white matter.

Authors:  Grazyna B Sadowska; Steven W Threlkeld; Alexia Flangini; Surendra Sharma; Barbara S Stonestreet
Journal:  Int J Dev Neurosci       Date:  2012-06-12       Impact factor: 2.457

4.  Effects of interleukin-6 on the expression of tight junction proteins in isolated cerebral microvessels from yearling and adult sheep.

Authors:  Susan S Cohen; May Min; Erin E Cummings; Xiaodi Chen; Grazyna B Sadowska; Surendra Sharma; Barbara S Stonestreet
Journal:  Neuroimmunomodulation       Date:  2013-07-18       Impact factor: 2.492

5.  The vitamin-E analog trolox and the NMDA antagonist MK-801 protect pyramidal neurons in hippocampal slice cultures from IL-1beta-induced neurodegeneration.

Authors:  Ann-Cathrin Radesäter; Sara Johansson; Caroline Oberg; Johan Luthman
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

6.  Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury.

Authors:  Roberta Brambilla; Valerie Bracchi-Ricard; Wen-Hui Hu; Beata Frydel; Annmarie Bramwell; Shaffiat Karmally; Edward J Green; John R Bethea
Journal:  J Exp Med       Date:  2005-07-04       Impact factor: 14.307

7.  Effects of FR-91 on immune cells from healthy individuals and from patients with non-Hodgkin lymphoma.

Authors:  V R M Lombardi; E Martínez; R Chacón; I Etcheverría; R Cacabelos
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  7 in total

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