Literature DB >> 12044969

Expression of Golli proteins in adult human brain and multiple sclerosis lesions.

R Filipovic1, S Rakic, N Zecevic.   

Abstract

It has been suggested that Golli proteins, structurally related to myelin basic proteins (MBPs), have a role in autoimmune processes. We studied the expression of these proteins in multiple sclerosis (MS) and determined that the number of Golli-immunoreactive (ir) cells was significantly higher around lesions of chronic MS than in control white matter. Golli proteins were expressed in the adult oligodendrocyte precursor cells (OPCs), activated microglia/macrophages, and some demyelinated axons around MS lesions. Their expression in adult OPCs indicates remyelination attempts, whereas the expression in the subpopulation of microglia/macrophages suggests roles in the immune processes of MS. In addition, Golli proteins may be markers of axonal transection, which is characteristic for MS.

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Year:  2002        PMID： 12044969     DOI： 10.1016/s0165-5728(02)00070-x

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  9 in total

1.  Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene.

Authors:  Pablo M Paez; Daniel Fulton; Vilma Spreuer; Vance Handley; Anthony T Campagnoni
Journal:  J Neurosci       Date:  2011-03-09       Impact factor: 6.167

Review 2.  Myelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoforms.

Authors:  George Harauz; Joan M Boggs
Journal:  J Neurochem       Date:  2013-03-06       Impact factor: 5.372

3.  Immunodominant fragments of myelin basic protein initiate T cell-dependent pain.

Authors:  Huaqing Liu; Sergey A Shiryaev; Andrei V Chernov; Youngsoon Kim; Igor Shubayev; Albert G Remacle; Svetlana Baranovskaya; Vladislav S Golubkov; Alex Y Strongin; Veronica I Shubayev
Journal:  J Neuroinflammation       Date:  2012-06-07       Impact factor: 8.322

4.  Transcriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brain.

Authors:  Rangarajan Parakalan; Boran Jiang; Baby Nimmi; Manivannan Janani; Manikandan Jayapal; Jia Lu; Samuel S W Tay; Eng-Ang Ling; S Thameem Dheen
Journal:  BMC Neurosci       Date:  2012-06-14       Impact factor: 3.288

5.  Defective structural RNA processing in relapsing-remitting multiple sclerosis.

Authors:  Charles F Spurlock; John T Tossberg; Yan Guo; Subramaniam Sriram; Philip S Crooke; Thomas M Aune
Journal:  Genome Biol       Date:  2015-03-25       Impact factor: 13.583

Review 6.  The multiple roles of myelin protein genes during the development of the oligodendrocyte.

Authors:  Daniel Fulton; Pablo M Paez; Anthony T Campagnoni
Journal:  ASN Neuro       Date:  2010-02-01       Impact factor: 4.146

7.  Regulation of store-operated and voltage-operated Ca2+ channels in the proliferation and death of oligodendrocyte precursor cells by golli proteins.

Authors:  Pablo M Paez; Daniel J Fulton; Vilma Spreuer; Vance Handley; Celia W Campagnoni; Anthony T Campagnoni
Journal:  ASN Neuro       Date:  2009-04-14       Impact factor: 4.146

8.  Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis.

Authors:  Sergey A Shiryaev; Alexei Y Savinov; Piotr Cieplak; Boris I Ratnikov; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Journal:  PLoS One       Date:  2009-03-20       Impact factor: 3.240

9.  Oligodendrocyte development and the onset of myelination in the human fetal brain.

Authors:  Igor Jakovcevski; Radmila Filipovic; Zhicheng Mo; Sonja Rakic; Nada Zecevic
Journal:  Front Neuroanat       Date:  2009-06-01       Impact factor: 3.856
  9 in total

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