Literature DB >> 12044878

Identification of G protein-coupled receptor genes from the human genome sequence.

Shigeki Takeda1, Shiro Kadowaki, Tatsuya Haga, Hirotomo Takaesu, Shigeki Mitaku.   

Abstract

We have identified novel G protein-coupled receptors (GPCRs) with no introns in the coding region from the human genome sequence: 322 olfactory receptors; 22 taste receptors; 128 registered GPCRs for endogenous ligands; 50 novel GPCR candidates homologous to registered GPCRs for endogenous ligands; and 59 novel GPCR candidates not homologous to registered GPCRs. The total number of GPCRs with and without introns in the human genome was estimated to be approximately 950, of which 500 are odorant or taste receptors and 450 are receptors for endogenous ligands.

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Year:  2002        PMID： 12044878     DOI： 10.1016/s0014-5793(02)02775-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  112 in total

Review 1.  Recent advances in drug action and therapeutics: relevance of novel concepts in G-protein-coupled receptor and signal transduction pharmacology.

Authors:  C B Brink; B H Harvey; J Bodenstein; D P Venter; D W Oliver
Journal:  Br J Clin Pharmacol       Date:  2004-04       Impact factor: 4.335

Review 2.  The significance of G protein-coupled receptor crystallography for drug discovery.

Authors:  John A Salon; David T Lodowski; Krzysztof Palczewski
Journal:  Pharmacol Rev       Date:  2011-12       Impact factor: 25.468

3.  Computational molecular biology approaches to ligand-target interactions.

Authors:  Paola Lupieri; Chuong Ha Hung Nguyen; Zhaleh Ghaemi Bafghi; Alejandro Giorgetti; Paolo Carloni
Journal:  HFSP J       Date:  2009-03-10

Review 4.  Ins and outs of GPCR signaling in primary cilia.

Authors:  Kenneth Bødtker Schou; Lotte Bang Pedersen; Søren Tvorup Christensen
Journal:  EMBO Rep       Date:  2015-08-21       Impact factor: 8.807

Review 5.  GRK2: multiple roles beyond G protein-coupled receptor desensitization.

Authors:  Tama Evron; Tanya L Daigle; Marc G Caron
Journal:  Trends Pharmacol Sci       Date:  2012-01-23       Impact factor: 14.819

6.  Detection of pairwise residue proximity by covariation analysis for 3D-structure prediction of G-protein-coupled receptors.

Authors:  Wataru Nemoto; Takashi Imai; Takuya Takahashi; Takeshi Kikuchi; Norihisa Fujita
Journal:  Protein J       Date:  2004-08       Impact factor: 2.371

Review 7.  Oligomerization of G protein-coupled receptors: past, present, and future.

Authors:  Paul S-H Park; Slawomir Filipek; James W Wells; Krzysztof Palczewski
Journal:  Biochemistry       Date:  2004-12-21       Impact factor: 3.162

8.  The origins of diversity and specificity in g protein-coupled receptor signaling.

Authors:  Stuart Maudsley; Bronwen Martin; Louis M Luttrell
Journal:  J Pharmacol Exp Ther       Date:  2005-04-01       Impact factor: 4.030

9.  Mechanism of Hormone Peptide Activation of a GPCR: Angiotensin II Activated State of AT1R Initiated by van der Waals Attraction.

Authors:  Khuraijam Dhanachandra Singh; Hamiyet Unal; Russell Desnoyer; Sadashiva S Karnik
Journal:  J Chem Inf Model       Date:  2019-01-16       Impact factor: 4.956

10.  Biophysical and structural investigation of bacterially expressed and engineered CCR5, a G protein-coupled receptor.

Authors:  Maciej Wiktor; Sébastien Morin; Hans-Jürgen Sass; Fabian Kebbel; Stephan Grzesiek
Journal:  J Biomol NMR       Date:  2012-12-11       Impact factor: 2.835
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