Sex differences in the acquisition of a radial maze task in the CD-1 mouse.

The purpose of the present study was to investigate spatial processing performance in male and female CD-1 mice. A substantial literature supports the existence of significant sex differences in both human and rodent models of learning and memory. The nature of these differences is dependent upon the parameters of the task, species and strain of animal. In the present study, male and female CD-1 mice were trained for 3 days to perform a 4/8 spatial memory task in an eight-arm radial maze and then tested for a total of 5 days. On the final day of radial maze testing, male CD-1 mice committed marginally significantly fewer reference memory (RM) and significantly fewer working memory (WM) errors on the radial maze task than female CD-1 mice. In addition, female mice obtained significantly fewer rewards during the final two testing sessions. The present data provide the first evidence for sex differences in radial maze learning in the CD-1 mouse, a strain known for its estrogen insensitivity. Consistent with the majority of literature that supports sex differences in spatial processing in rodents, female CD-1 mice acquired significantly fewer rewards than male CD-1 mice during an eight-arm radial maze task.