| Literature DB >> 12043192 |
Masashi Inoue1, Kazuhiko Nakamura, Kazuhiko Iwahashi, Kiyoshi Ameno, Masahiro Itoh, Hiroshi Suwaki.
Abstract
To characterize the biochemical mechanism of cell death induced by ethanol intoxication, we examined expression of mRNAs of bcl-2 and bax genes in the brain, which are related to apoptosis, by using the reverse transcription-polymerase chain reaction method (RT-PCR). According to ethanol administrations, the expression of bcl-2 mRNA in the cerebral cortex decreased after 1 day and be recovered after 3 days. The expression of bcl-2 mRNA in the cerebellum was not changed soon after 1 day and increased after 3 days. The expression of bax mRNA in the cerebral cortex decreased after 1 day and be recovered after 3 days. The expression of bax mRNA in the cerebellum increased after 1 day and after 3 days. We found that bcl-2 or bax mRNA expressions in the brain were changed after short-term ethanol exposure. These results suggest that bcl-2 or bax may have functional significance about ethanol intoxication.Entities:
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Year: 2002 PMID： 12043192
Source DB: PubMed Journal: Nihon Arukoru Yakubutsu Igakkai Zasshi ISSN： 1341-8963