L-tetramisole. Enhancement of human lymphocyte response to antigen.

The anthelminthic drug L-Tetramisole enhanced in vitro lymphocyte transformation of normal young adults in the presence of PPD, Candida or measles antigen. This enhancement occurred regardless of evident pre-existing immunity to the antigen used. The increase in stimulation obtained by the drug and antigen combined, beyond that by antigen alone, varied between 1-25 and 5-99 for all three antigens in fourteen cell donors. Lymphocyte transformation was induced in seven individuals by the drug alone and suppressed in two. In levamisole dose--response tests, the optimum dose for this in vitro effect in six donors was similar for the three antigens.