Literature DB >> 12039779

Production of sepiapterin in Escherichia coli by coexpression of cyanobacterial GTP cyclohydrolase I and human 6-pyruvoyltetrahydropterin synthase.

Hyun Joo Woo1, Jee Yun Kang, Yong Kee Choi, Young Shik Park.   

Abstract

Synechocystis sp. strain PCC 6803 GTP cyclohydrolase I and human 6-pyruvoyltetrahydropterin synthase were coexpressed in Escherichia coli. The E. coli transformant produced sepiapterin, which was identified by high-performance liquid chromatography and enzymatically converted to dihydrobiopterin by sepiapterin reductase. Aldose reductase, another indispensable enzyme for sepiapterin production, may be endogenous in E. coli.

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Year:  2002        PMID： 12039779      PMCID： PMC123912          DOI： 10.1128/AEM.68.6.3138-3140.2002

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  15 in total

1.  Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?

Authors:  C P Tiefenbacher
Journal:  Am J Physiol Heart Circ Physiol       Date:  2001-06       Impact factor: 4.733

2.  L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin.

Authors:  R Heller; A Unbehaun; B Schellenberg; B Mayer; G Werner-Felmayer; E R Werner
Journal:  J Biol Chem       Date:  2001-01-05       Impact factor: 5.157

Review 3.  Aldo-keto reductases.

Authors:  B Wermuth
Journal:  Prog Clin Biol Res       Date:  1985

Review 4.  Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.

Authors:  C A Nichol; G K Smith; D S Duch
Journal:  Annu Rev Biochem       Date:  1985       Impact factor: 23.643

5.  Identification of the yqhE and yafB genes encoding two 2, 5-diketo-D-gluconate reductases in Escherichia coli.

Authors:  D Y Yum; B Y Lee; J G Pan
Journal:  Appl Environ Microbiol       Date:  1999-08       Impact factor: 4.792

Review 6.  Tetrahydrobiopterin biosynthesis, regeneration and functions.

Authors:  B Thöny; G Auerbach; N Blau
Journal:  Biochem J       Date:  2000-04-01       Impact factor: 3.857

7.  Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase.

Authors:  P Steinerstauch; B Wermuth; W Leimbacher; H C Curtius
Journal:  Biochem Biophys Res Commun       Date:  1989-11-15       Impact factor: 3.575

8.  Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

Authors:  S S Gross; R Levi
Journal:  J Biol Chem       Date:  1992-12-25       Impact factor: 5.157

9.  Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.

Authors:  Y S Park; C W Heizmann; B Wermuth; R A Levine; P Steinerstauch; J Guzman; N Blau
Journal:  Biochem Biophys Res Commun       Date:  1991-03-29       Impact factor: 3.575

10.  The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl tetrahydropterin (2'-oxo)reductase.

Authors:  S Milstien; S Kaufman
Journal:  J Biol Chem       Date:  1989-05-15       Impact factor: 5.157
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  3 in total

1.  Purification, crystallization and preliminary crystallographic analysis of a 6-pyruvoyltetrahydropterin synthase homologue from Esherichia coli.

Authors:  Kyung Hye Seo; Hye Lim Kim; Young Shik Park; Che Ok Jeon; Kon Ho Lee
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-02-01

2.  Molecular investigation of the radiation resistance of edible cyanobacterium Arthrospira sp. PCC 8005.

Authors:  Hanène Badri; Pieter Monsieurs; Ilse Coninx; Ruddy Wattiez; Natalie Leys
Journal:  Microbiologyopen       Date:  2015-02-12       Impact factor: 3.139

3.  Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial cells.

Authors:  Yang Su; Syed M Qadri; Lingyun Wu; Lixin Liu
Journal:  Cardiovasc Diabetol       Date:  2013-09-19       Impact factor: 9.951
  3 in total

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