| Literature DB >> 12039634 |
Michael J Lovdahl1, Timothy R Hurley, Brian Tobias, Stephen R Priebe.
Abstract
Seven degradation products observed in formulated pregabalin have been characterized. These compounds result from Maillard reactions and Amadori rearrangements. Heating pregabalin in the presence of lactose formed significant quantities of these degradation products. The seven compounds corresponding to the observed degradation products were isolated by preparative liquid chromatography. The synthesis, isolation, and spectral characterization of the degradation products are detailed.Entities:
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Year: 2002 PMID： 12039634 DOI： 10.1016/s0731-7085(01)00710-5
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935