Literature DB >> 12039590

Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.

David J Calderwood1, David N Johnston, Rainer Munschauer, Paul Rafferty.   

Abstract

A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available lck inhibitor which inhibited TCR mediated IL-2 production after oral dosing.

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Year:  2002        PMID： 12039590     DOI： 10.1016/s0960-894x(02)00195-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

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7.  Efficient solution-phase synthesis of 4,5,7-trisubstituted pyrrolo[3,2-d]pyrimidines.

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Review 10.  Does B cell receptor signaling in chronic lymphocytic leukaemia cells differ from that in other B cell types?

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  10 in total

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