Literature DB >> 12039585

Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.

John D Buynak1, Lakshminarayana Vogeti, Venkata Ramana Doppalapudi, George Martin Solomon, Hansong Chen.   

Abstract

New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases.

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Year:  2002        PMID： 12039585     DOI： 10.1016/s0960-894x(02)00205-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Use of beta-lactamase inhibitors in disk tests to detect plasmid-mediated AmpC beta-lactamases.

Authors:  Jennifer A Black; Kenneth S Thomson; Johann D D Pitout
Journal:  J Clin Microbiol       Date:  2004-05       Impact factor: 5.948

2.  Evaluation of beta-lactamase inhibitors in disk tests for detection of plasmid-mediated AmpC beta-lactamases in well-characterized clinical strains of Klebsiella spp.

Authors:  Jennifer A Black; Kenneth S Thomson; John D Buynak; Johann D D Pitout
Journal:  J Clin Microbiol       Date:  2005-08       Impact factor: 5.948

3.  In vitro and in vivo activities of novel 6-methylidene penems as beta-lactamase inhibitors.

Authors:  William J Weiss; Peter J Petersen; Timothy M Murphy; Luanna Tardio; Youjun Yang; Patricia A Bradford; Aranapakam M Venkatesan; Takao Abe; Takeshi Isoda; Ado Mihira; Hideki Ushirogochi; Tsuyoshi Takasake; Steve Projan; John O'Connell; Tarek S Mansour
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

4.  β-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: allylic transposition and formation of an unprecedented stabilized acyl-enzyme.

Authors:  Elizabeth A Rodkey; David C McLeod; Christopher R Bethel; Kerri M Smith; Yan Xu; Weirui Chai; Tao Che; Paul R Carey; Robert A Bonomo; Focco van den Akker; John D Buynak
Journal:  J Am Chem Soc       Date:  2013-12-03       Impact factor: 15.419

5.  Penicillin sulfone inhibitors of class D beta-lactamases.

Authors:  Sarah M Drawz; Christopher R Bethel; Venkata R Doppalapudi; Anjaneyulu Sheri; Sundar Ram Reddy Pagadala; Andrea M Hujer; Marion J Skalweit; Vernon E Anderson; Shu G Chen; John D Buynak; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2010-01-19       Impact factor: 5.191

6.  Direct diazo-transfer reaction on beta-lactam: synthesis and preliminary biological activities of 6-triazolylpenicillanic acids.

Authors:  Po C Chen; Rebekah E Wharton; Pratiq A Patel; Adegboyega K Oyelere
Journal:  Bioorg Med Chem       Date:  2007-08-25       Impact factor: 3.641

Review 7.  Three decades of beta-lactamase inhibitors.

Authors:  Sarah M Drawz; Robert A Bonomo
Journal:  Clin Microbiol Rev       Date:  2010-01       Impact factor: 26.132
  7 in total

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