Literature DB >> 12039580

Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes.

Stefano Alcaro1, Cinzia Anna Ventura, Donatella Paolino, Danilo Battaglia, Francesco Ortuso, Luigi Cattel, Giovanni Puglisi, Massimo Fresta.   

Abstract

Paclitaxel (PTX) was complexed with beta-cyclodextrin (1), 2,6-dimethyl-beta-cyclodextrin (2) and 2,3,6-trimethyl-beta-cyclodextrin (3). PTX-CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement with molecular modeling analysis, which showed different PTX-CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12039580     DOI： 10.1016/s0960-894x(02)00217-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Formulation optimization of paclitaxel carried by PEGylated emulsions based on artificial neural network.

Authors:  Tianyuan Fan; Kozo Takayama; Yoshiyuki Hattori; Yoshie Maitani
Journal:  Pharm Res       Date:  2004-09       Impact factor: 4.200

Review 2.  Pharmacological effects of formulation vehicles : implications for cancer chemotherapy.

Authors:  Albert J ten Tije; Jaap Verweij; Walter J Loos; Alex Sparreboom
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

3.  Molecular Inclusion Complexes of β-Cyclodextrin Derivatives Enhance Aqueous Solubility and Cellular Internalization of Paclitaxel: Preformulation and In vitro Assessments.

Authors:  Milin Shah; Vatsal Shah; Anasuya Ghosh; Zheng Zhang; Tamara Minko
Journal:  J Pharm Pharmacol (Los Angel)       Date:  2015-01-10

4.  Polysaccharide-gold nanocluster supramolecular conjugates as a versatile platform for the targeted delivery of anticancer drugs.

Authors:  Nan Li; Yong Chen; Ying-Ming Zhang; Yang Yang; Yue Su; Jia-Tong Chen; Yu Liu
Journal:  Sci Rep       Date:  2014-02-25       Impact factor: 4.379

5.  The Rheolaser Master™ and Kinexus Rotational Rheometer® to Evaluate the Influence of Topical Drug Delivery Systems on Rheological Features of Topical Poloxamer Gel.

Authors:  Maria Chiara Cristiano; Francesca Froiio; Antonia Mancuso; Federica De Gaetano; Cinzia Anna Ventura; Massimo Fresta; Donatella Paolino
Journal:  Molecules       Date:  2020-04-23       Impact factor: 4.411

Review 6.  A Promising Review on Cyclodextrin Conjugated Paclitaxel Nanoparticles for Cancer Treatment.

Authors:  Kamini Velhal; Sagar Barage; Arpita Roy; Jaya Lakkakula; Ramesh Yamgar; Mohammed S Alqahtani; Krishna Kumar Yadav; Yongtae Ahn; Byong-Hun Jeon
Journal:  Polymers (Basel)       Date:  2022-08-03       Impact factor: 4.967

7.  Folate-appended cyclodextrin carrier targets ovarian cancer cells expressing the proton-coupled folate transporter.

Authors:  Shinichi Saito; Yoshihiro Koya; Hiroaki Kajiyama; Mamoru Yamashita; Fumitaka Kikkawa; Akihiro Nawa
Journal:  Cancer Sci       Date:  2020-04-03       Impact factor: 6.716
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.