| Literature DB >> 12039572 |
Masayuki Nakamura1, Jun Inoue.
Abstract
A series of peptidyl hydrazones was synthesized, and their inhibitory activity against mu-calpain and water-solubility were measured. Among these compounds, N,N-dimethyl glycyl hydrazone 6, which inhibited mu-calpain with IC(50) of 0.37 microM, possessed the appropriate water-solubility. Furthermore, hydrazone 6 was found to possess the excellent in vitro metabolic stability.Entities:
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Year: 2002 PMID： 12039572 DOI： 10.1016/s0960-894x(02)00226-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823