Literature DB >> 12039559

The use of dioxygen by HIF prolyl hydroxylase (PHD1).

Luke A McNeill1, Kirsty S Hewitson, Jonathan M Gleadle, Louise E Horsfall, Neil J Oldham, Patrick H Maxwell, Christopher W Pugh, Peter J Ratcliffe, Christopher J Schofield.   

Abstract

The hypoxic response in animals is mediated by hydroxylation of proline residues in the alpha-subunit of hypoxia inducible factor (HIF). Hydroxylation is catalysed by prolyl-4-hydroxylases (PHD isozymes in humans) which are iron(II) and 2-oxoglutarate dependent oxygenases. Mutation of the arginine proposed to bind 2-oxoglutarate and of the 2His-1-carboxylate iron(II) binding motif in PHD1 dramatically reduces its activity. The source of the oxygen of the product alcohol is (>95%) dioxygen.

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Year:  2002        PMID： 12039559     DOI： 10.1016/s0960-894x(02)00219-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  22 in total

1.  Chlamydomonas reinhardtii has multiple prolyl 4-hydroxylases, one of which is essential for proper cell wall assembly.

Authors:  Katriina Keskiaho; Reija Hieta; Raija Sormunen; Johanna Myllyharju
Journal:  Plant Cell       Date:  2007-01-12       Impact factor: 11.277

Review 2.  Sirtuins and the Metabolic Hurdles in Cancer.

Authors:  Natalie J German; Marcia C Haigis
Journal:  Curr Biol       Date:  2015-06-29       Impact factor: 10.834

Review 3.  Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.

Authors:  Nanduri R Prabhakar; Gregg L Semenza
Journal:  Physiol Rev       Date:  2012-07       Impact factor: 37.312

Review 4.  Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?

Authors:  Yanqing Huang; Daniel Lin; Cullen M Taniguchi
Journal:  Sci China Life Sci       Date:  2017-10-13       Impact factor: 6.038

5.  Potential regulation of glioma through the induction of apoptosis signaling via Egl-9 family hypoxia-inducible factor 3.

Authors:  Ke Mao; Chao You; Ding Lei; Heng Zhang
Journal:  Oncol Lett       Date:  2016-12-14       Impact factor: 2.967

6.  Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro.

Authors:  Yi Pan; Kyle D Mansfield; Cara C Bertozzi; Viktoriya Rudenko; Denise A Chan; Amato J Giaccia; M Celeste Simon
Journal:  Mol Cell Biol       Date:  2006-11-13       Impact factor: 4.272

7.  Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

Authors:  Annelies Quaegebeur; Inmaculada Segura; Roberta Schmieder; Dries Verdegem; Ilaria Decimo; Francesco Bifari; Tom Dresselaers; Guy Eelen; Debapriva Ghosh; Shawn M Davidson; Sandra Schoors; Dorien Broekaert; Bert Cruys; Kristof Govaerts; Carla De Legher; Ann Bouché; Luc Schoonjans; Matt S Ramer; Gene Hung; Goele Bossaert; Don W Cleveland; Uwe Himmelreich; Thomas Voets; Robin Lemmens; C Frank Bennett; Wim Robberecht; Katrien De Bock; Mieke Dewerchin; Bart Ghesquière; Sarah-Maria Fendt; Peter Carmeliet
Journal:  Cell Metab       Date:  2016-01-07       Impact factor: 27.287

8.  Rapid degradation of hypoxia-inducible factor-1alpha by KRH102053, a new activator of prolyl hydroxylase 2.

Authors:  H J Choi; B-J Song; Y-D Gong; W J Gwak; Y Soh
Journal:  Br J Pharmacol       Date:  2008-03-10       Impact factor: 8.739

9.  Distribution and prediction of catalytic domains in 2-oxoglutarate dependent dioxygenases.

Authors:  Siddhartha Kundu
Journal:  BMC Res Notes       Date:  2012-08-04

Review 10.  Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum.

Authors:  Susanne Schlisio
Journal:  J Cell Mol Med       Date:  2009-08-19       Impact factor: 5.310
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