Vibratory proprioceptive stimulation affects Parkinsonian tremor.

Previous research on tremor pathophysiology showed that tremor can be affected, e.g. by electrical stimulation of the peripheral nerve, mechanical perturbation of the limb and by transcranial magnetic stimulation of the motor cortex. This report is focused on possible effects of muscle vibration (MV) on resting tremor in Parkinson's Disease (PD). Vibratory stimulation was applied to the tendons of M. extensor carpi radialis longus and M. flexor ulnaris in 27 subjects with moderate PD resting tremor. The following effects were observed: (1) tremor stopped or started time-locked to MV onset and offset, (2) tremor persisted during MV but its frequency pattern changed. These results are discussed with specific emphasis to effects of MV on spinal and supraspinal levels.