Literature DB >> 1203917

Haemodynamic effects of a new anti-arrhythmic agent, mexiletine (Kö 1173) in ischaemic heart disease.

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Abstract

The haemodynamic effects of mexiletine (Kö 1173) were studied in six patients. Heart rate and cardiac output remained unchanged. The systemic arterial pressure was reduced in two patients owing to a fall in the peripheral resistance. Cardiac function, assessed by means of the stroke work and pulmonary capillary wedge pressure, was depressed in three patients, who all had a current or past history of severe heart failure.

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Year:  1975        PMID： 1203917     DOI： 10.1093/cvr/9.6.788

Source DB:  PubMed          Journal:  Cardiovasc Res        ISSN： 0008-6363            Impact factor:   10.787


  6 in total

Review 1.  Mexiletine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias.

Authors:  J P Monk; R N Brogden
Journal:  Drugs       Date:  1990-09       Impact factor: 9.546

2.  Long-term oral antiarrhythmic therapy with mexiletine.

Authors:  N P Campbell; J F Pantridge; A A Adgey
Journal:  Br Heart J       Date:  1978-07

Review 3.  Adverse effects of antiarrhythmic drugs.

Authors:  J B Schwartz; D Keefe; D C Harrison
Journal:  Drugs       Date:  1981-01       Impact factor: 9.546

Review 4.  Mexiletine: a review of its pharmacological properties and therapeutic efficacy in arrhythmias.

Authors:  C Y Chew; J Collett; B N Singh
Journal:  Drugs       Date:  1979-03       Impact factor: 9.546

5.  Observations on haemodynamic effects of mexiletine.

Authors:  N P Campbell; S A Zaidi; A A Adgey; G C Patterson; J F Pantridge
Journal:  Br Heart J       Date:  1979-02

Review 6.  New antiarrhythmic drugs.

Authors:  P F Nestico; J Morganroth; L N Horowitz
Journal:  Drugs       Date:  1988-03       Impact factor: 9.546
  6 in total

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