| Literature DB >> 12039054 |
Chuzhao Lin1, Solida Mak, Patricia A Meitner, Jennifer M Wolf, Eric M Bluman, Joel A Block, Richard M Terek.
Abstract
Differential display-polymerase chain reaction was used to compare gene expression between human chondrosarcoma cell lines and normal cartilage. A new gene, CSAGE, has been cloned and belongs to a gene family that includes the taxol resistance associated gene (TRAG)-3. CSAGE, like TRAG-3, does not confer resistance to taxol when transfected in vitro. Both genes have alternatively spliced variants. CSAGE and TRAG-3 are expressed in chondrosarcoma, melanoma, and cartilage and testis, but not in other normal tissues. TRAG-3 has been reported to be a cancer/testis antigen. Our results suggest that CSAGE belongs to the growing list of cancer/testis antigens as well. In all of the CSAGE positive samples, the melanoma antigen gene family was also expressed. This is the first report on the expression of cancer/testis antigens in chondrosarcoma.Entities:
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Year: 2002 PMID： 12039054 DOI： 10.1016/s0378-1119(02)00395-5
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688