BACKGROUND: Recent reports have shown elevated concentrations of serum cystatin C (CC) in patients with solid tumours. The aim of our study was to investigate whether patients with proliferative haematological disorders have increased serum concentrations of CC compared with normal subjects. METHODS: Full blood count, serum CC, beta2-microglobulin (beta2M) and serum creatinine were determined in 27 apparently healthy subjects and 35 patients with proliferative haematological disorders. Creatinine clearance was calculated using the Cockroft-Gault formula. RESULTS: CC and beta2M showed a significant correlation with each other (r=0.96, P<0.0001). Serum beta2M (P=0.001) and the serum beta2M:CC ratio (P=0.001) were significantly higher in the patients with normal renal function than in controls, but serum CC was not significantly different (P=0.08). CC did not show a significant correlation with blood count parameters. DISCUSSION: Compared with beta2M and the beta2M:CC ratio, serum CC is not influenced by cell proliferation in haematological disorders.
BACKGROUND: Recent reports have shown elevated concentrations of serum cystatin C (CC) in patients with solid tumours. The aim of our study was to investigate whether patients with proliferative haematological disorders have increased serum concentrations of CC compared with normal subjects. METHODS: Full blood count, serum CC, beta2-microglobulin (beta2M) and serum creatinine were determined in 27 apparently healthy subjects and 35 patients with proliferative haematological disorders. Creatinine clearance was calculated using the Cockroft-Gault formula. RESULTS:CC and beta2M showed a significant correlation with each other (r=0.96, P<0.0001). Serum beta2M (P=0.001) and the serum beta2M:CC ratio (P=0.001) were significantly higher in the patients with normal renal function than in controls, but serum CC was not significantly different (P=0.08). CC did not show a significant correlation with blood count parameters. DISCUSSION: Compared with beta2M and the beta2M:CC ratio, serum CC is not influenced by cell proliferation in haematological disorders.
Authors: Holger Nückel; Christian Langer; Stefan Herget-Rosenthal; Marc Wichert; Roland Assert; Hartmut Döhner; Ulrich Dührsen; Peter Liebisch Journal: Int J Hematol Date: 2012-03-18 Impact factor: 2.490
Authors: Marika H Grönroos; Timo Jahnukainen; Kerttu Irjala; Risto Härkönen; Saija Hurme; Merja Möttönen; Toivo T Salmi Journal: Pediatr Nephrol Date: 2008-01-23 Impact factor: 3.714
Authors: Pierre Delanaye; Bernard Lambermont; Jean-Paul Chapelle; Jacques Gielen; Paul Gerard; Georges Rorive Journal: Intensive Care Med Date: 2004-02-24 Impact factor: 17.440