BACKGROUND: Isotretinoin has been proven to be an effective treatment for acne vulgaris. The enclosed package insert with isotretinoin suggests weekly/biweekly laboratory testing (hepatic functions and lipid analysis) but fails to recommend the needed action levels for abnormalities. METHODS: We provide a statistical analysis of a retrospective study of 141 individuals' course of therapy on isotretinoin and their laboratory blood analysis results. RESULTS: Very few statistically significant elevations in liver enzymes or lipid profiles occurred. More importantly, in only 1 case did these elevations warrant the discontinuation of therapy. CONCLUSION: The data presented here support the conclusion that limited blood testing should be performed for most patients and that more complete blood testing be done only for those patients with a significant response in liver enzymes, cholesterol or triglycerides. A set of guidelines is proposed for the practicing physician to interpret blood test results. Copyright 2002 S. Karger AG, Basel
BACKGROUND:Isotretinoin has been proven to be an effective treatment for acne vulgaris. The enclosed package insert with isotretinoin suggests weekly/biweekly laboratory testing (hepatic functions and lipid analysis) but fails to recommend the needed action levels for abnormalities. METHODS: We provide a statistical analysis of a retrospective study of 141 individuals' course of therapy on isotretinoin and their laboratory blood analysis results. RESULTS: Very few statistically significant elevations in liver enzymes or lipid profiles occurred. More importantly, in only 1 case did these elevations warrant the discontinuation of therapy. CONCLUSION: The data presented here support the conclusion that limited blood testing should be performed for most patients and that more complete blood testing be done only for those patients with a significant response in liver enzymes, cholesterol or triglycerides. A set of guidelines is proposed for the practicing physician to interpret blood test results. Copyright 2002 S. Karger AG, Basel
Authors: John S Barbieri; Daniel B Shin; Shiyu Wang; David J Margolis; Junko Takeshita Journal: J Am Acad Dermatol Date: 2019-06-19 Impact factor: 11.527
Authors: Amal A Mohamed; Alshymaa Hassnine; Amr Elsayed; Mahmoud Montaser; Yasmeen Ismail; Ahmed El-Demery; Eman Sultan; Rania S Abdel Aziz; Eman Eldemiry; Radwa Hagag; Amal A El-Kholy; Eman Salah Journal: Pharmgenomics Pers Med Date: 2021-12-24