Literature DB >> 12036378

One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.

Bernard L Flynn1, Ernest Hamel, M Katherine Jung.   

Abstract

Benzo[b]furan and indole analogues of some recently identified benzo[b]thiophene inhibitors of tubulin polymerization have been prepared, and their biological activity has been assessed. Several very potent analogues were identified.

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Year:  2002        PMID： 12036378     DOI： 10.1021/jm020077t

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  20 in total

1.  Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006).

Authors:  Matthew T Macdonough; Tracy E Strecker; Ernest Hamel; John J Hall; David J Chaplin; Mary Lynn Trawick; Kevin G Pinney
Journal:  Bioorg Med Chem       Date:  2013-07-23       Impact factor: 3.641

2.  Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.

Authors:  Mallinath B Hadimani; Matthew T Macdonough; Anjan Ghatak; Tracy E Strecker; Ramona Lopez; Madhavi Sriram; Benson L Nguyen; John J Hall; Raymond J Kessler; Anupama R Shirali; Li Liu; Charles M Garner; George R Pettit; Ernest Hamel; David J Chaplin; Ralph P Mason; Mary Lynn Trawick; Kevin G Pinney
Journal:  J Nat Prod       Date:  2013-09-09       Impact factor: 4.050

3.  Solution-phase parallel synthesis of a multi-substituted benzo[b]thiophene library.

Authors:  Chul-Hee Cho; Benjamin Neuenswander; Gerald H Lushington; Richard C Larock
Journal:  J Comb Chem       Date:  2009 Sep-Oct

4.  Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Filippo Prencipe; Carlota Lopez-Cara; Santiago Schiaffino Ortega; Andrea Brancale; Ernest Hamel; Ignazio Castagliuolo; Stefania Mitola; Roberto Ronca; Roberta Bortolozzi; Elena Porcù; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2015-03-26       Impact factor: 7.446

5.  Highly potent triazole-based tubulin polymerization inhibitors.

Authors:  Qiang Zhang; Youyi Peng; Xin I Wang; Susan M Keenan; Sonia Arora; William J Welsh
Journal:  J Med Chem       Date:  2007-01-24       Impact factor: 7.446

6.  Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; Carlota Lopez Cara; Olga Cruz-Lopez; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosaria Pipitone; Jan Balzarini; Nicola Zonta; Andrea Brancale; Ernest Hamel
Journal:  Bioorg Med Chem       Date:  2009-08-20       Impact factor: 3.641

7.  Parallel synthesis of a multi-substituted benzo[b]furan library.

Authors:  Chul-Hee Cho; Benjamin Neuenswander; Gerald H Lushington; Richard C Larock
Journal:  J Comb Chem       Date:  2008-10-21

8.  Efficient Microwave-assisted One-pot Three-component Synthesis of 2,3-Disubstituted Benzofurans under Sonogashira Conditions.

Authors:  Nataliya A Markina; Yu Chen; Richard C Larock
Journal:  Tetrahedron       Date:  2013-04       Impact factor: 2.457

9.  Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Taradas Sarkar; Maria Dora Carrion; Olga Cruz-Lopez; Carlota Lopez Cara; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosaria Pipitone; Jan Balzarini; Roberto Gambari; Lampronti Ilaria; Roberto Saletti; Andrea Brancale; Ernest Hamel
Journal:  Bioorg Med Chem       Date:  2008-08-17       Impact factor: 3.641

10.  (Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.

Authors:  M V Ramana Reddy; Balaiah Akula; Stephen C Cosenza; Clement M Lee; Muralidhar R Mallireddigari; Venkat R Pallela; D R C Venkata Subbaiah; Andrew Udofa; E Premkumar Reddy
Journal:  J Med Chem       Date:  2012-05-25       Impact factor: 7.446
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