| Literature DB >> 12036362 |
George R Pettit1, Matthew P Grealish, M Katherine Jung, Ernest Hamel, Robin K Pettit, J-Charles Chapuis, Jean M Schmidt.
Abstract
As an extension of structure/activity investigations of resveratrol (1), phenstatin (2c), and the cancer antiangiogenesis drug sodium combretastatin A-4 phosphate (2b), syntheses of certain related stilbenes (14) and benzophenones (16) were undertaken. The trimethyl ether derivative of (Z)-resveratrol (4a) exhibited the strongest activity (GI(50) = 0.01-0.001 microg/mL) against a minipanel of human cancer cell lines. A monodemethylated derivative (14c) was converted to prodrug 14n (sodium resverastatin phosphate) for further biological evaluation. The antitubulin and antimicrobial activities of selected compounds were also evaluated.Entities:
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Year: 2002 PMID： 12036362 DOI： 10.1021/jm010119y
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446