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Literature DB >> 12036028

Synthesis of 2-alkoxy 1,4-naphthoquinone derivatives as antiplatelet, antiinflammatory, and antiallergic agents.

Jin-Cherng Lien¹, Li-Jiau Huang, Che-Ming Teng, Jih-Pyang Wang, Sheng-Chu Kuo.

Abstract

In our continuing search for novel antiplatelet, antiallergic, and antiinflammatory agents, 2-alkoxy derivatives of 1,4-naphthoquinone were prepared. Some of these compounds showed significant antiplatelet, antiallergic, and antiinflammatory activities. Among them, 2-propoxy-1,4-naphthoquinone and 2-butoxy-1,4-naphthoquinone exhibited potent inhibitory effect on neutrophil superoxide anion formation. These two compounds are worthy of further exploration.

Entities: Chemical

Mesh：

Substances：

Year: 2002 PMID： 12036028 DOI： 10.1248/cpb.50.672

Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645

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Cited

6 in total

1. NP-313, 2-acetylamino-3-chloro-1,4-naphthoquinone, a novel antithrombotic agent with dual inhibition of thromboxane A(2) synthesis and calcium entry.

Authors: Heng-Lan Kuo; Jin-Cherng Lien; Chien-Hsin Chang; Ching-Hu Chung; Sheng-Chu Kuo; Chun-Chieh Hsu; Hui-Chin Peng; Tur-Fu Huang
Journal: Br J Pharmacol Date: 2011-04 Impact factor: 8.739

2. Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.

Authors: Yiyu Ge; Aslamuzzaman Kazi; Frank Marsilio; Yunting Luo; Sanjula Jain; Wesley Brooks; Kenyon G Daniel; Wayne C Guida; Saïd M Sebti; Harshani R Lawrence
Journal: J Med Chem Date: 2012-02-14 Impact factor: 7.446

3. A novel naphthoquinone derivative shows selective antifungal activity against Sporothrix yeasts and biofilms.

Authors: Luana P Borba-Santos; Caroline Deckmann Nicoletti; Taissa Vila; Patricia Garcia Ferreira; Carlos Fernando Araújo-Lima; Bárbara Verena Dias Galvão; Israel Felzenszwalb; Wanderley de Souza; Fernando de Carvalho da Silva; Vitor Francisco Ferreira; Debora Omena Futuro; Sonia Rozental
Journal: Braz J Microbiol Date: 2022-03-08 Impact factor: 2.214

Synthesis of 2-alkoxy 1,4-naphthoquinone derivatives as antiplatelet, antiinflammatory, and antiallergic agents.

1. NP-313, 2-acetylamino-3-chloro-1,4-naphthoquinone, a novel antithrombotic agent with dual inhibition of thromboxane A(2) synthesis and calcium entry.

2. Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.

3. A novel naphthoquinone derivative shows selective antifungal activity against Sporothrix yeasts and biofilms.

4. Aromatase inhibitory activity of 1,4-naphthoquinone derivatives and QSAR study.

5. Alkoxy and Enediyne Derivatives Containing 1,4-Benzoquinone Subunits-Synthesis and Antitumor Activity.

Review 6. The diverse mechanisms and anticancer potential of naphthoquinones.