Literature DB >> 12036021

Synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole.

Alicia Hernández-Campos1, Froylán Ibarra-Velarde, Yolanda Vera-Montenegro, Norma Rivera-Fernández, Rafael Castillo.   

Abstract

The synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole (6) is described. Compound 6 showed 100% activity in vitro at 146.70 and 29.34 microM concentrations. It also completely removed 3-d and 10-week-old Fasciola hepatica in sheep at a dose of 15 mg/kg.

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Year:  2002        PMID： 12036021     DOI： 10.1248/cpb.50.649

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  11 in total

1.  Efficacy of an experimental fasciolicide against immature and mature Fasciola hepatica in artificially infected calves.

Authors:  Y Vera Montenegro; F Ibarra Velarde; E Liébano Hernández; H Quiroz Romero; R Castillo Bocanegra; A Hernández Campos; P Ochoa Galván
Journal:  Parasitol Res       Date:  2003-12-03       Impact factor: 2.289

2.  Surface changes in adult Fasciola hepatica following treatment in vivo with the experimental fasciolicide, compound alpha.

Authors:  M McConville; G P Brennan; A Flanagan; R E B Hanna; H W J Edgar; R Castillo; A Hernández-Campos; I Fairweather
Journal:  Parasitol Res       Date:  2009-05-21       Impact factor: 2.289

3.  Immature triclabendazole-resistant Fasciola hepatica: tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha.

Authors:  M McConville; G P Brennan; M McCoy; R Castillo; A Hernandez-Campos; F Ibarra; I Fairweather
Journal:  Parasitol Res       Date:  2006-10-03       Impact factor: 2.289

4.  The effect of the 5-chloro-2-methylthio-6-(1-naphtyloxy)-1H-benzimidazole on the tegument of immature Fasciola hepatica in their natural host.

Authors:  Norma Rivera; Froylán Ibarra; Armando Zepeda; Teresa Fortoul; Germinal Cantó; Alicia Hernández; Rafael Castillo
Journal:  Parasitol Res       Date:  2005-02-25       Impact factor: 2.289

5.  Field trial on the efficacy of an experimental fasciolicide compared with some commercial compounds in naturally infected cattle.

Authors:  Y Vera Montenegro; F Ibarra Velarde; H Quiroz Romero; A Hernández Campos; R Castillo
Journal:  Parasitol Res       Date:  2003-07-03       Impact factor: 2.289

6.  RCB20, an experimental benzimidazole derivative, affects tubulin expression and induces gross anatomical changes in Taenia crassiceps cysticerci.

Authors:  Adrián Márquez-Navarro; América Pérez-Reyes; Armando Zepeda-Rodríguez; Olivia Reynoso-Ducoing; Alicia Hernández-Campos; Francisco Hernández-Luis; Rafael Castillo; Lilian Yépez-Mulia; Javier R Ambrosio
Journal:  Parasitol Res       Date:  2013-03-17       Impact factor: 2.289

7.  Morphological response of triclabendazole-susceptible and triclabendazole-resistant isolates of Fasciola hepatica to treatment in vitro with nitroxynil (Trodax).

Authors:  B McKinstry; L Halferty; G P Brennan; I Fairweather
Journal:  Parasitol Res       Date:  2008-11-18       Impact factor: 2.289

8.  Paramphistomicidal efficacy of an experimental compound in sheep.

Authors:  P M Reyes; V F Ibarra; M Y Vera; A G Cantó; A Hernández; C A Hernández; R Castillo; M A Villa
Journal:  Parasitol Res       Date:  2008-01-10       Impact factor: 2.289

9.  Tegumental surface changes in adult Fasciola hepatica following treatment in vitro and in vivo with an experimental fasciolicide.

Authors:  Norma Rivera; Froylán Ibarra; Armando Zepeda; Teresa Fortoul; Alicia Hernández; Rafael Castillo; Germinal Cantó
Journal:  Parasitol Res       Date:  2004-05-25       Impact factor: 2.289

10.  5-Chloro-2-methyl-sulfanyl-6-(naphtha-len-1-yl-oxy)-1H-benzimidazole methanol monosolvate.

Authors:  Miguel Flores-Ramos; Rafael Castillo; Alicia Hernández-Campos; Marcos Flores-Alamo
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-12-21
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